PDB entry 3f91

View 3f91 on RCSB PDB site
Description: Structural Data for Human Active Site Mutant Enzyme Complexes
Class: oxidoreductase
Keywords: active site mutants ligand complex DHFR, NADP, One-carbon metabolism, Oxidoreductase
Deposited on 2008-11-13, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-04-30, with a file datestamp of 2014-04-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.182
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHFR, DHFRP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00374 (Start-186)
      • engineered (35)
      • engineered (64)
    Domains in SCOPe 2.08: d3f91a_
  • Heterogens: DH1, NDP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3f91A (A:)
mvgslncivavsqnmgigkngdlpwpplrnefryfsrmtttssvegkqnlvimgkktwfs
ipekfrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd

    Sequence, based on observed residues (ATOM records): (download) 
    >3f91A (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfsrmtttssvegkqnlvimgkktwfsi
pekfrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd