PDB entry 3f8y

View 3f8y on RCSB PDB site
Description: Correlations of Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes
Class: oxidoreductase
Keywords: active site mutants ligand complex DHFR, NADP, One-carbon metabolism, Oxidoreductase
Deposited on 2008-11-13, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHFR, DHFRP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00374 (Start-186)
      • engineered (35)
    Domains in SCOPe 2.08: d3f8ya_
  • Heterogens: DH1, NDP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3f8yA (A:)
mvgslncivavsqnmgigkngdlpwpplrnefryfkrmtttssvegkqnlvimgkktwfs
ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd

    Sequence, based on observed residues (ATOM records): (download) 
    >3f8yA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfkrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd