PDB entry 3f8g

View 3f8g on RCSB PDB site
Description: The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities
Class: hydrolase
Keywords: antitumor agent, ribonuclease, 3d domain swapping, unswapped dimer, dimers, Endonuclease, Glycoprotein, Hydrolase, Nuclease, Secreted
Deposited on 2008-11-12, released 2009-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-10, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.215
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: ribonuclease pancreatic
  Species: Homo sapiens [TaxId:9606]
  Gene: RNASE1, RIB1, RNS1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07998 (0-124)
    • engineered (27)
    • engineered (30-31)
    • engineered (33)
    • engineered (110)
  Domains in SCOPe 2.08: d3f8ga_
• Chain 'B':
  Compound: ribonuclease pancreatic
  Species: Homo sapiens [TaxId:9606]
  Gene: RNASE1, RIB1, RNS1
  Database cross-references and differences (RAF-indexed):
  • Uniprot P07998 (0-124)
    • engineered (27)
    • engineered (30-31)
    • engineered (33)
    • engineered (110)
  Domains in SCOPe 2.08: d3f8gb_
• Heterogens: SO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3f8gA (A:)
  kesrakkfqrqhmdsdsspsssstycnlmmccrkmtqgrckpvntfvheplvdvqnvcfq
  ekvtckngqgncyksnssmhitdcrltngsrypncayrtspkerhiivacggspyvpvhf
  dasve
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3f8gB (B:)
  kesrakkfqrqhmdsdsspsssstycnlmmccrkmtqgrckpvntfvheplvdvqnvcfq
  ekvtckngqgncyksnssmhitdcrltngsrypncayrtspkerhiivacggspyvpvhf
  dasve