PDB entry 3f7i

View 3f7i on RCSB PDB site
Description: Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Class: apoptosis
Keywords: ZINC BINDING, PEPTIDE COMPLEX, APOPTOSIS INHIBITION, PEPTIDOMIMETIC, SMALL MOLECULE, DRUG DESIGN, Apoptosis, Metal-binding, Nucleus, Zinc-finger
Deposited on 2008-11-09, released 2009-03-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.156
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Baculoviral IAP repeat-containing protein 7
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC7, KIAP, LIVIN, MLIAP, RNF50, UNQ5800/PRO19607/PRO21344
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6R308
      • engineered (110)
      • engineered (120-127)
    Domains in SCOPe 2.06: d3f7ia_
  • Chain 'B':
    Compound: Baculoviral IAP repeat-containing protein 7
    Species: Homo sapiens [TaxId:9606]
    Gene: BIRC7, KIAP, LIVIN, MLIAP, RNF50, UNQ5800/PRO19607/PRO21344
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6R308
      • engineered (110)
      • engineered (120-128)
    Domains in SCOPe 2.06: d3f7ib_
  • Heterogens: ZN, G13, LI, BTB, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3f7iA (A:)
mgsshhhhhhssgevprgshmleteeeeeegagatlsrgpafpgmgseelrlasfydwpl
taevppellaaagffhtghqdkvrcffcygglqswkrgddpwtehakwfpgcqfllrskg
qeyinnihlthsl

    Sequence, based on observed residues (ATOM records): (download) 
    >3f7iA (A:)
gpafpgmgseelrlasfydwpltaevppellaaagffhtghqdkvrcffcygglqswkrg
ddpwtehakwfpgcqfllrskgqeyinnih

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3f7iB (B:)
mgsshhhhhhssgevprgshmleteeeeeegagatlsrgpafpgmgseelrlasfydwpl
taevppellaaagffhtghqdkvrcffcygglqswkrgddpwtehakwfpgcqfllrskg
qeyinnihlthsl

    Sequence, based on observed residues (ATOM records): (download) 
    >3f7iB (B:)
gpafpgmgseelrlasfydwpltaevppellaaagffhtghqdkvrcffcygglqswkrg
ddpwtehakwfpgcqfllrskgqeyinnihlth