PDB entry 3f69

View 3f69 on RCSB PDB site
Description: Crystal structure of the Mycobacterium tuberculosis PknB mutant kinase domain in complex with KT5720
Class: transferase
Keywords: protein kinase, PknB, Mycobacterium tuberculosis, KT5720, Structural Genomics, Structual Genomics, Cocrystallization of PknB kinase domain and inhibitors, TB Structural Genomics Consortium, TBSGC, ATP-binding, Kinase, Magnesium, Metal-binding, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase
Deposited on 2008-11-05, released 2008-12-02
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.221
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase pknb
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT0017, MTCY10H4.14c, pknB, Rv0014c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5S4
      • engineered (35)
      • engineered (147)
      • engineered (157)
    Domains in SCOPe 2.04: d3f69a_
  • Chain 'B':
    Compound: serine/threonine-protein kinase pknb
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT0017, MTCY10H4.14c, pknB, Rv0014c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5S4
      • engineered (35)
      • engineered (147)
      • engineered (157)
    Domains in SCOPe 2.04: d3f69b_
  • Heterogens: XDR, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3f69A (A:)
gshmttpshlsdryelgeilgfggmsevhlardlrdhrdvavkvlradlardpsfylrfr
reaqnaaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraie
viadacqalnfshqngiihrdvkpanilisatnavkvvdfgiaraiadsgnsvtqtaavi
gtaqylspeqargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpipps
arheglsadldavvlkalaknpenryqtaaemradlvrvhngeppeapkvltdaertsll
ssaagnlsgpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3f69A (A:)
tpshlsdryelgeilgfggmsevhlardlrdhrdvavkvlradlardpsfylrfrreaqn
aaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraieviada
cqalnfshqngiihrdvkpanilisatnavkvvdfgiaraitaqylspeqargdsvdars
dvyslgcvlyevltgeppftgdspvsvayqhvredpippsarheglsadldavvlkalak
npenryqtaaemradlvrvhngeppeapkv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3f69B (B:)
gshmttpshlsdryelgeilgfggmsevhlardlrdhrdvavkvlradlardpsfylrfr
reaqnaaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraie
viadacqalnfshqngiihrdvkpanilisatnavkvvdfgiaraiadsgnsvtqtaavi
gtaqylspeqargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpipps
arheglsadldavvlkalaknpenryqtaaemradlvrvhngeppeapkvltdaertsll
ssaagnlsgpr

    Sequence, based on observed residues (ATOM records): (download) 
    >3f69B (B:)
ttpshlsdryelgeilgfggmsevhlardlrdhrdvavkvlradlardpsfylrfrreaq
naaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraieviad
acqalnfshqngiihrdvkpanilisatnavkvvdfgiaraiadsgnsvtqtigtaqyls
peqargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpippsarhegls
adldavvlkalaknpenryqtaaemradlvrvhngeppeapkv