PDB entry 3f2s

View 3f2s on RCSB PDB site
Description: Crystal structure of human choline kinase alpha in complex with hemicholinium-3 and ADP
Class: transferase
Keywords: NON-PROTEIN KINASE, CHOLINE KINASE, STRUCTURAL GENOMICS Consortium, SGC, hemicholinium-3, Alternative splicing, Cytoplasm, Kinase, Transferase
Deposited on 2008-10-30, released 2008-11-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-10, with a file datestamp of 2009-02-06.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.215
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: choline kinase alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CHKA, CHK, CKI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35790 (Start-400)
      • variant (163)
      • variant (365)
      • engineered (163)
      • engineered (365)
    Domains in SCOPe 2.08: d3f2sa_
  • Chain 'B':
    Compound: choline kinase alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CHKA, CHK, CKI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35790 (Start-400)
      • variant (163)
      • variant (365)
      • engineered (163)
      • engineered (365)
    Domains in SCOPe 2.08: d3f2sb_
  • Heterogens: ADP, MG, HC6, PO4, UNX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3f2sA (A:)
gsshhhhhhssglvprgspqppadeqpeprtrrraylwckeflpgawrglredefhisvi
rgglsnmlfqcslpdttatlgdeprkvllrlygailqmrscnkegseqaqkenefqgaea
mvlesvmfailaerslgpklygifpqgrleqfipsrrldteelslpdisaeiaekmatfh
gmkmpfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlplelenlrsllest
pspvvfchndcqegnilllegrensekqklmlidfeyssynyrgfdignhfcewmydysy
ekypffranirkyptkkqqlhfissylpafqndfenlsteeksiikeemllevnrfalas
hflwglwsivqakissiefgymdyaqarfdayfhqkrklgv

    Sequence, based on observed residues (ATOM records): (download) 
    >3f2sA (A:)
eqpeprtrrraylwckeflpgawrglredefhisvirgglsnmlfqcslpdttatlgdep
rkvllrlygaaeamvlesvmfailaerslgpklygifpqgrleqfipsrrldteelslpd
isaeiaekmatfhgmkmpfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlp
lelenlrsllestpspvvfchndcqegnilllegrensekqklmlidfeyssynyrgfdi
gnhfcewmydysyekypffranirkyptkkqqlhfissylpafqndfenlsteeksiike
emllevnrfalashflwglwsivqakissiefgymdyaqarfdayfhqkrklgv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3f2sB (B:)
gsshhhhhhssglvprgspqppadeqpeprtrrraylwckeflpgawrglredefhisvi
rgglsnmlfqcslpdttatlgdeprkvllrlygailqmrscnkegseqaqkenefqgaea
mvlesvmfailaerslgpklygifpqgrleqfipsrrldteelslpdisaeiaekmatfh
gmkmpfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlplelenlrsllest
pspvvfchndcqegnilllegrensekqklmlidfeyssynyrgfdignhfcewmydysy
ekypffranirkyptkkqqlhfissylpafqndfenlsteeksiikeemllevnrfalas
hflwglwsivqakissiefgymdyaqarfdayfhqkrklgv

    Sequence, based on observed residues (ATOM records): (download) 
    >3f2sB (B:)
rrraylwckeflpawmlfqcvllrlmvlesvmfailaerslgpklygifpqgrleqfips
rrldteelslpdisaeiaekmatfhgmkmpfnkepkwlfgtmekylkevlrikfteesri
kklhkllsynlplelenlrsllestpspvvfchndcqegnilllegrensekqklmlidf
eyssynyrgfdignhfcewmydysyekypffranirkyptkkqqlhfissylpafqndfe
nlsteeksiikeemllevnrfalashflwglwsivqakissiefgymdyaqarfdayfhq
krklgv