PDB entry 3f1q

View 3f1q on RCSB PDB site
Description: Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 1
Class: Oxidoreductase
Keywords: Dihydroorotate dehydrogenase, leflunomide, FAD, Flavoprotein, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Pyrimidine biosynthesis, Transit peptide
Deposited on 2008-10-28, released 2009-06-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.179
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3f1qa_
  • Heterogens: FMN, ORO, BCE, ACY, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3f1qA (A:)
    matgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfr
    npvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygf
    nshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladyl
    vvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedia
    svvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvp
    iigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtda
    igadhrr
    

    Sequence, based on observed residues (ATOM records): (download)
    >3f1qA (A:)
    gderfyaehlmptlqglldpesahrlavrftslgllpfqdsdmlevrvlghkfrnpvgia
    agfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfnshgls
    vvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvvnvss
    pntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasvvkel
    gidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpiigvgg
    vssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaigadhr
    r