PDB entry 3f18
View 3f18 on RCSB PDB site
Description: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor 4-fluoro-N-(2-hydroxyethyl)-N-(2-nitroso-2-oxoethyl)benzenesulfonamide
Class: hydrolase
Keywords: MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, Zymogen
Deposited on
2008-10-27, released
2008-11-18
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.13 Å
R-factor: 0.168
AEROSPACI score: 0.87
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3f18a_ - Heterogens: ZN, CA, HS5, HOH