PDB entry 3f16
View 3f16 on RCSB PDB site
Description: Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-N-(3-hydroxy-1-nitroso-1-oxopropan-2-yl)-4-methoxybenzenesulfonamide
Class: hydrolase
Keywords: MATRIX METALLOPROTEINASE, MMP12, ELASTASE, COMPLEX (ELASTASE/INHIBITOR), METALLO ELASTASE, CALCIUM, EXTRACELLULAR MATRIX, GLYCOPROTEIN, HYDROLASE, METAL-BINDING, METALLOPROTEASE, POLYMORPHISM, PROTEASE, SECRETED, ZINC, Zymogen
Deposited on
2008-10-27, released
2008-11-18
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 1.16 Å
R-factor: 0.163
AEROSPACI score: 0.85
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Macrophage metalloelastase
Species: Homo sapiens [TaxId:9606]
Gene: HME, MMP12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3f16a_ - Heterogens: ZN, CA, HS3, HOH