PDB entry 3ewj

View 3ewj on RCSB PDB site
Description: Crystal structure of catalytic domain of TACE with carboxylate inhibitor
Class: Hydrolase
Keywords: TACE, ADAM17, HYDROLASE, Cleavage on pair of basic residues, Glycoprotein, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Phosphoprotein, Protease, SH3-binding, Transmembrane, Zymogen
Deposited on 2008-10-15, released 2008-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.181
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adam 17
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (51)
      • engineered (138)
      • engineered (237)
    Domains in SCOPe 2.08: d3ewja_
  • Chain 'B':
    Compound: adam 17
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM17, CSVP, TACE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P78536
      • engineered (51)
      • engineered (138)
      • engineered (237)
    Domains in SCOPe 2.08: d3ewjb_
  • Heterogens: ZN, INN, 642, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ewjA (A:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkvgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ewjA (A:)
pdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygi
qieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahl
ftyqdfdmgtlglayggsphggvcpkayyspvgkkniylnsgltstknygktiltkeadl
vtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiykt
ieskaqecfqersn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ewjB (B:)
radpdpmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkg
ygiqieqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvcl
ahlftyqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygkti
ltkeadlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcs
kqsiyktieskaqecfqersnkvgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ewjB (B:)
pmkntckllvvadhrfyrymgrgeestttnylielidrvddiyrntawdnagfkgygiqi
eqirilkspqevkpgekhynmaksypneekdawdvkmlleqfsfdiaeeaskvclahlft
yqdfdmgtlglayggspranshggvcpkayyspvgkkniylnsgltstknygktiltkea
dlvtthelghnfgaehdpdglaecapnedqggkyvmypiavsgdhennkmfsqcskqsiy
ktieskaqecfqers