PDB entry 3ewh

View 3ewh on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a pyridyl-pyrimidine benzimidazole inhibitor
Class: Transferase
Keywords: angiogenesis, receptor tyrosine kinase, DFG-out, Transferase
Deposited on 2008-10-15, released 2009-08-25
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-08-25, with a file datestamp of 2009-08-21.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.206
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (0-124)
      • engineered (2)
      • engineered (101)
    • Uniprot P35968 (125-306)
      • engineered (125)
      • expression tag (307-311)
    Domains in SCOPe 2.04: d3ewha_
  • Heterogens: K11, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ewhA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ewhA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidtcrtvavkmlkegaths
ehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvp
ykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdf
glardpdyvrlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefc
rrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhh