PDB entry 3ew8

View 3ew8 on RCSB PDB site
Description: Crystal Structure Analysis of human HDAC8 D101L variant
Class: hydrolase
Keywords: hydrolase, HDAC, metalloenzyme, arginase fold, HDAC8, histone deacetylase, hydroxamate inhibitor, unliganded, Chromatin regulator, Nucleus, Repressor, Transcription, Transcription regulation
Deposited on 2008-10-14, released 2008-12-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.176
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: CDA07, HDAC8, HDACL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered (100)
      • expression tag (377)
    Domains in SCOPe 2.08: d3ew8a1, d3ew8a2
  • Heterogens: K, ZN, B3N, BME, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ew8A (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgylcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ew8A (A:)
lvpvyiyspeyvsmcdslakipkrasmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegeyglgylcpategifdyaaaiggatitaaqclidgmckvainwsggw
hhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtvslh
kfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpkavv
lqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyltgv
ilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvvi