PDB entry 3et1

View 3et1 on RCSB PDB site
Description: Structure of PPARalpha with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid
Class: Transcription/Transferase
Keywords: PPAR, PPARa, PPARalpha, Drug Discovery, Diabetes, adiponectin, metabolic disease, fragment-based drug discovery, scaffold-based drug discovery, Activator, DNA-binding, Metal-binding, Nucleus, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger, Acyltransferase, Alternative splicing, Chromosomal rearrangement, Phosphoprotein, Proto-oncogene, Transferase, Ubl conjugation, Transcription/Transferase COMPLEX
Deposited on 2008-10-06, released 2009-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-17, with a file datestamp of 2009-02-13.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.198
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARA, NR1C1, PPAR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3et1a_
  • Chain 'B':
    Compound: Peroxisome proliferator-activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PPARA, NR1C1, PPAR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3et1b_
  • Chain 'P':
    Compound: steroid receptor coactivator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA1, SRC1
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: steroid receptor coactivator 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA1, SRC1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ET1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3et1A (A:)
mgsshhhhhhssglvprgshmetadlkslakriyeaylknfnmnkvkarvilsgkasnnp
pfvihdmetlcmaektlvaklvangiqnkeaevrifhccqctsvetvteltefakaipgf
anldlndqvtllkygvyeaifamlssvmnkdgmlvaygngfitreflkslrkpfcdimep
kfdfamkfnalelddsdislfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhp
ddiflfpkllqkmadlrqlvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >3et1A (A:)
etadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaqn
keaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifamlssvm
nkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaaiicc
gdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvtehaqlvq
iikktesdaalhpllqeiyrdmy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3et1B (B:)
mgsshhhhhhssglvprgshmetadlkslakriyeaylknfnmnkvkarvilsgkasnnp
pfvihdmetlcmaektlvaklvangiqnkeaevrifhccqctsvetvteltefakaipgf
anldlndqvtllkygvyeaifamlssvmnkdgmlvaygngfitreflkslrkpfcdimep
kfdfamkfnalelddsdislfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhp
ddiflfpkllqkmadlrqlvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >3et1B (B:)
etadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvakl
vangiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaif
amlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislf
vaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvt
ehaqlvqiikktesdaalhpllqeiyrdmy

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.