PDB entry 3esv

View 3esv on RCSB PDB site
Description: Crystal structure of the engineered neutralizing antibody M18
Class: immune system
Keywords: single-chain FV, monoclonal antibody, immunoglobulin, IMMUNE SYSTEM
Deposited on 2008-10-06, released 2009-04-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-04-28, with a file datestamp of 2009-04-24.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.194
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'F':
    Compound: Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3ESV (5-112)
      • expression tag (3-4)
      • engineered (25)
      • engineered (50)
      • engineered (60)
      • engineered (80)
      • engineered (82)
      • engineered (98)
      • linker (113)
      • engineered (162)
      • engineered (190)
      • engineered (197)
      • engineered (201)
    • PDB 3ESV (Start-251)
      • expression tag (3-4)
      • engineered (25)
      • engineered (50)
      • engineered (60)
      • engineered (80)
      • engineered (82)
      • engineered (98)
      • linker (113)
      • engineered (162)
      • engineered (190)
      • engineered (197)
      • engineered (201)
    Domains in SCOPe 2.06: d3esvf1, d3esvf2, d3esvf3
  • Chain 'G':
    Compound: Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 3ESV (5-112)
      • expression tag (3-4)
      • engineered (25)
      • engineered (50)
      • engineered (60)
      • engineered (80)
      • engineered (82)
      • engineered (98)
      • linker (113)
      • engineered (162)
      • engineered (190)
      • engineered (197)
      • engineered (201)
    • PDB 3ESV (Start-251)
      • expression tag (3-4)
      • engineered (25)
      • engineered (50)
      • engineered (60)
      • engineered (80)
      • engineered (82)
      • engineered (98)
      • linker (113)
      • engineered (162)
      • engineered (190)
      • engineered (197)
      • engineered (201)
    Domains in SCOPe 2.06: d3esvg1, d3esvg2, d3esvg3
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3esvF (F:)
madykdiqmtqttsslsaslgdrvtvscrasqdirnylnwyqqkpdgtvkfliyytsrlq
pgvpsrfsgsgsgtdysltinnleqedigtyfcqqgntppwtfgggtkleikrggggsgg
ggsggggsggggsevqlqqsgpelvkpgasvkisckdsgyafnsswmnwvkqrpgqglew
igriypgdgdsnyngkfegkailtadkssstaymqlssltsvdsavyfcarsgllryamd
ywgqgtsvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >3esvF (F:)
ykdiqmtqttsslsaslgdrvtvscrasqdirnylnwyqqkpdgtvkfliyytsrlqpgv
psrfsgsgsgtdysltinnleqedigtyfcqqgntppwtfgggtkleikrgvqlqqsgpe
lvkpgasvkisckdsgyafnsswmnwvkqrpgqglewigriypgdgdsnyngkfegkail
tadkssstaymqlssltsvdsavyfcarsgllryamdywgqgtsvtvss

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3esvG (G:)
madykdiqmtqttsslsaslgdrvtvscrasqdirnylnwyqqkpdgtvkfliyytsrlq
pgvpsrfsgsgsgtdysltinnleqedigtyfcqqgntppwtfgggtkleikrggggsgg
ggsggggsggggsevqlqqsgpelvkpgasvkisckdsgyafnsswmnwvkqrpgqglew
igriypgdgdsnyngkfegkailtadkssstaymqlssltsvdsavyfcarsgllryamd
ywgqgtsvtvss

    Sequence, based on observed residues (ATOM records): (download) 
    >3esvG (G:)
ykdiqmtqttsslsaslgdrvtvscrasqdirnylnwyqqkpdgtvkfliyytsrlqpgv
psrfsgsgsgtdysltinnleqedigtyfcqqgntppwtfgggtkleikrgqlqqsgpel
vkpgasvkisckdsgyafnsswmnwvkqrpgqglewigriypgdgdsnyngkfegkailt
adkssstaymqlssltsvdsavyfcarsgllryamdywgqgtsvtvss