SCOPe 2.08: Structural Classification of Proteins

PDB entry 3eql

View 3eql on RCSB PDB site
Description: Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin
Class: transferase
Keywords: RNA POLYMERASE HOLOENZYME, MYXOPYRONIN, ANTIBIOTIC, TRANSCRIPTION REGULATION, DNA-directed RNA polymerase, Nucleotidyltransferase, Transcription, Transferase, DNA-binding, Sigma factor
Deposited on 2008-09-30, released 2008-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-01-20, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.24
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: DNA-directed RNA polymerase subunit alpha
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.08: d3eqla1, d3eqla2
Chain 'B':
Compound: DNA-directed RNA polymerase subunit alpha
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.08: d3eqlb1, d3eqlb2
Chain 'C':
Compound: DNA-directed RNA polymerase subunit beta
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE9 (0-1118)
Domains in SCOPe 2.08: d3eqlc_
Chain 'D':
Compound: DNA-directed RNA polymerase subunit beta'
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE8
Domains in SCOPe 2.08: d3eqld_
Chain 'E':
Compound: DNA-directed RNA polymerase subunit omega
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE7
Domains in SCOPe 2.08: d3eqle_
Chain 'F':
Compound: RNA polymerase sigma factor rpoD
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q72L95 (Start-422)
Domains in SCOPe 2.08: d3eqlf1, d3eqlf2, d3eqlf3
Chain 'K':
Compound: DNA-directed RNA polymerase subunit alpha
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.08: d3eqlk1, d3eqlk2
Chain 'L':
Compound: DNA-directed RNA polymerase subunit alpha
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9Z9H6 (0-End)
Domains in SCOPe 2.08: d3eqll1, d3eqll2
Chain 'M':
Compound: DNA-directed RNA polymerase subunit beta
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE9 (0-1118)
Domains in SCOPe 2.08: d3eqlm_
Chain 'N':
Compound: DNA-directed RNA polymerase subunit beta'
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE8
Domains in SCOPe 2.08: d3eqln_
Chain 'O':
Compound: DNA-directed RNA polymerase subunit omega
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8RQE7
Domains in SCOPe 2.08: d3eqlo_
Chain 'P':
Compound: RNA polymerase sigma factor rpoD
Species: Thermus thermophilus [TaxId:274]
Database cross-references and differences (RAF-indexed):
- Uniprot Q72L95 (Start-422)
Domains in SCOPe 2.08: d3eqlp1, d3eqlp2, d3eqlp3
Heterogens: ZN, MXP, MG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3eqlA (A:)
mldsklkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyied
vlhefstipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadv
eimnpdlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafq
vedtrlgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnpqaaavaapeeak
epeappeqeeeldlpleelglstrvlhslkeegiesvrallalnlkdlknipgigersle
eikealekkgftlke