PDB entry 3eob

View 3eob on RCSB PDB site
Description: Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II
Deposited on 2008-09-26, released 2009-04-14
The last revision was dated 2009-04-14, with a file datestamp of 2009-04-10.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: 0.267
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Efalizumab Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IGG1
    Database cross-references and differences (RAF-indexed):
    • PDB 3EOB (0-213)
  • Chain 'B':
    Compound: Efalizumab Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IGG1
    Database cross-references and differences (RAF-indexed):
    • PDB 3EOB (0-219)
  • Chain 'H':
    Compound: Efalizumab Fab fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IGG1
    Database cross-references and differences (RAF-indexed):
    • PDB 3EOB (0-219)
  • Chain 'I':
    Compound: Integrin alpha-L
    Species: Homo sapiens [TaxId:9606]
    Gene: LFA-1 I domain
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Integrin alpha-L
    Species: Homo sapiens [TaxId:9606]
    Gene: LFA-1 I domain
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Efalizumab Fab fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: IGG1
    Database cross-references and differences (RAF-indexed):
    • PDB 3EOB (0-213)
  • Heterogens: ZN

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >3eobA (A:)
diqmtqspsslsasvgdrvtitcrasktiskylawyqqkpgkapklliysgstlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqhneypltfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3eobB (B:)
evqlvesggglvqpggslrlscaasgysftghwmnwvrqapgkglewvgmihpsdsetry
nqkfkdrftisvdkskntlylqmnslraedtavyycargiyfygttyfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve

    Sequence, based on observed residues (ATOM records):
    >3eobB (B:)
evqlvesggglvqpggslrlscaasgysftghwmnwvrqapgkglewvgmihpsdsetry
nqkfkdrftisvdkskntlylqmnslraedtavyycargiyfygttyfdywgqgtlvtvs
sastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkve

  • Chain 'H':
    Sequence, based on SEQRES records:
    >3eobH (H:)
evqlvesggglvqpggslrlscaasgysftghwmnwvrqapgkglewvgmihpsdsetry
nqkfkdrftisvdkskntlylqmnslraedtavyycargiyfygttyfdywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve

    Sequence, based on observed residues (ATOM records):
    >3eobH (H:)
evqlvesggglvqpggslrlscaasgysftghwmnwvrqapgkglewvgmihpsdsetry
nqkfkdrftisvdkskntlylqmnslraedtavyycargiyfygttyfdywgqgtlvtvs
sastkgpsvfplapssgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkve

  • Chain 'I':
    Sequence, based on SEQRES records:
    >3eobI (I:)
gnvdlvflfdgsmslqpdefqkildfmkdvmkklsntsyqfaavqfstsyktefdfsdyv
krkdpdallkhvkhmllltntfgainyvatevfreelgarpdatkvliiitdgeatdsgn
idaakdiiryiigigkhfqtkesqetlhkfaskpasefvkildtfeklkdlftelqkkiy
v

    Sequence, based on observed residues (ATOM records):
    >3eobI (I:)
gnvdlvflfdgsmslqpdefqkildfmkdvmkklsntsyqfaavqfstsyktefdfsdyv
krkdpdallkhvkhmllltntfgainyvatevfreelgarpdatkvliiitdgeatdsgn
idaakdiiryiigigkhfqtkesqetlhkfaskpasefvkildtfeklkdlftelqkki

  • Chain 'J':
    Sequence, based on SEQRES records:
    >3eobJ (J:)
gnvdlvflfdgsmslqpdefqkildfmkdvmkklsntsyqfaavqfstsyktefdfsdyv
krkdpdallkhvkhmllltntfgainyvatevfreelgarpdatkvliiitdgeatdsgn
idaakdiiryiigigkhfqtkesqetlhkfaskpasefvkildtfeklkdlftelqkkiy
v

    Sequence, based on observed residues (ATOM records):
    >3eobJ (J:)
gnvdlvflfdgsmslqpdefqkildfmkdvmkklsntsyqfaavqfstsyktefdfsdyv
krkdpdallkhvkhmllltntfgainyvatevfreelgarpdatkvliiitdgeatdsgn
idaakdiiryiigigkhfqtkesqetlhkfaskpasefvkildtfeklkdlftelqkki

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records:
    >3eobL (L:)
diqmtqspsslsasvgdrvtitcrasktiskylawyqqkpgkapklliysgstlqsgvps
rfsgsgsgtdftltisslqpedfatyycqqhneypltfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec