PDB entry 3ens

View 3ens on RCSB PDB site
Description: Crystal structure of human FXA in complex with methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]amino}acrylate
Class: hydrolase, blood clotting
Keywords: SERINE PROTEASE, HYDROLASE, EPIDERMAL GROWTH FACTOR LIKE DOMAIN, BLOOD COAGULATION FACTOR, Cleavage on pair of basic residues, EGF-like domain, Gamma-carboxyglutamic acid, Glycoprotein, Hydroxylation, Zymogen, BLOOD CLOTTING
Deposited on 2008-09-25, released 2008-12-30
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.225
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3ensa1, d3ensa2
  • Chain 'B':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3ensb_
  • Chain 'C':
    Compound: factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3ensc1, d3ensc2
  • Chain 'D':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3ensd_
  • Heterogens: ENS, CA, NA, MES, GOL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ensA (A:)
kdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfcheeq
nsvvcscargytladngkaciptgpypcgkqtle

    Sequence, based on observed residues (ATOM records): (download) 
    >3ensA (A:)
cspcqnqgkckdeytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscarg
ytladngkaciptgpypcgkqtle

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ensB (B:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ensC (C:)
kdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfcheeq
nsvvcscargytladngkaciptgpypcgkqtle

    Sequence, based on observed residues (ATOM records): (download) 
    >3ensC (C:)
qcepcqnqgkckdytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscarg
ytladngkaciptgpypcgkqtle

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ensD (D:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglp