PDB entry 3en7
View 3en7 on RCSB PDB site
Description: Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor
Class: transferase
Keywords: SRC, tyrosine, kinase, polypharmacology, inhibitor, multitarget, phosphoinositide, transferase, signaling, pyrazolopyrimidine, kinase-inhibitor complex, ATP-binding, Lipoprotein, Myristate, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Tyrosine-protein kinase
Deposited on
2008-09-25, released
2008-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-10-25, with a file datestamp of
2017-10-20.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: N/A
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3en7a_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase Src
Species: Gallus gallus [TaxId:9031]
Gene: SRC
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3en7b_ - Heterogens: ABJ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3en7A (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>3en7A (A:)
akdaweipreslrlevklgqgevwmgtwntrvaiktlkpflqeaqvmkklrheklvqlya
vvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdl
raanilvgenlvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgm
vnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepq
yqpgenl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3en7B (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl
Sequence, based on observed residues (ATOM records): (download)
>3en7B (B:)
weipreslrlevklgqgevwmgtwnttrvaiktlqvmkklrheklvqlyavvseepiyiv
teymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraanilvgen
lvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqve
rgyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl