PDB entry 3emg

View 3emg on RCSB PDB site
Description: Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
Class: transferase
Keywords: kinase, syk, Alternative splicing, ATP-binding, Host-virus interaction, Nucleotide-binding, Phosphoprotein, Polymorphism, SH2 domain, Transferase, Tyrosine-protein kinase, Ubl conjugation
Deposited on 2008-09-24, released 2008-12-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2008-12-02, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.2
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3emga_
  • Heterogens: 685, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3emgA (A:)
gslhespyadpeeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkil
kneandpalkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnr
hvkdkniielvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalraden
yykaqthgkwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtam
lekgermgcpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvn

    Sequence, based on observed residues (ATOM records): (download) 
    >3emgA (A:)
ldrklltledkelgsgnfgtvkkgyyqmkvvktvavkilklkdellaeanvmqqldnpyi
vrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesnfvh
rdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfssksdvw
sfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwtydvenr
pgfaavelrlrnyyy