PDB entry 3ekw

View 3ekw on RCSB PDB site
Description: Crystal structure of the inhibitor Atazanavir (ATV) in complex with a multi-drug resistance HIV-1 protease variant (L10I/G48V/I54V/V64I/V82A) Refer: FLAP+ in citation.
Class: hydrolase
Keywords: HIV-1, protease, multi-drug resistance, Atazanavir, AIDS, HYDROLASE
Deposited on 2008-09-19, released 2009-09-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.189
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: HIV-1 M:B_ARV2/SF2 [TaxId:11685]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03369 (0-98)
    • engineered (6)
    • engineered (9)
    • engineered (47)
    • engineered (53)
    • engineered (63)
    • engineered (81)
  Domains in SCOPe 2.04: d3ekwa_
• Chain 'B':
  Compound: Protease
  Species: HIV-1 M:B_ARV2/SF2 [TaxId:11685]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03369 (0-98)
    • engineered (6)
    • engineered (9)
    • engineered (47)
    • engineered (53)
    • engineered (63)
    • engineered (81)
  Domains in SCOPe 2.04: d3ekwb_
• Heterogens: PO4, DR7, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ekwA (A:)
  pqitlwkrpivtiriggqlkealldtgaddtvleemnlpgkwkpkmivgiggfvkvrqyd
  qipieicghkaigtvlvgptpaniigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >3ekwB (B:)
  pqitlwkrpivtiriggqlkealldtgaddtvleemnlpgkwkpkmivgiggfvkvrqyd
  qipieicghkaigtvlvgptpaniigrnlltqigctlnf