PDB entry 3ej1
View 3ej1 on RCSB PDB site
Description: CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor
Class: Transferase/Cell cycle
Keywords: cdk, cyclin, kinase, ATP-binding, Cell cycle, Cell division, Mitosis, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Nucleus, Transferase-Cell cycle COMPLEX
Deposited on
2008-09-17, released
2008-10-21
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-07-24, with a file datestamp of
2019-07-19.
Experiment type: XRAY
Resolution: 3.22 Å
R-factor: N/A
AEROSPACI score: 0.12
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3ej1b1, d3ej1b2 - Chain 'C':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2
Database cross-references and differences (RAF-indexed):
- Chain 'D':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3ej1d1, d3ej1d2 - Heterogens: 5BP
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3ej1B (B:)
nevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetl
hlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvl
rmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylp
sviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirek
yknskyhgvsllnppetlnl
Sequence, based on observed residues (ATOM records): (download)
>3ej1B (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl
- Chain 'C':
No sequence available.
- Chain 'D':
Sequence, based on SEQRES records: (download)
>3ej1D (D:)
nevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetl
hlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvl
rmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylp
sviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirek
yknskyhgvsllnppetlnl
Sequence, based on observed residues (ATOM records): (download)
>3ej1D (D:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
agaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykn
skyhgvsllnppetlnl