PDB entry 3egy

View 3egy on RCSB PDB site
Description: Crystal Structure of Human Thymidyalte Synthase A191K with Loop 181-197 stabilized in the inactive conformation
Class: transferase
Keywords: methyltransferase, Nucleotide biosynthesis, Transferase
Deposited on 2008-09-11, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: TYMS, TS, OK/SW-cl.29
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered (190)
    Domains in SCOPe 2.08: d3egyx_
  • Heterogens: SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >3egyX (X:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplmklppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3egyX (X:)
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstvygfqwrhfggvdqlqrvidtiktnpddrriimcawnprdlplmklppc
halcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgda
hiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm