PDB entry 3egi

View 3egi on RCSB PDB site
Description: Methyltransferase domain of human trimethylguanosine synthase TGS1 bound to m7GpppA (inactive form)
Deposited on 2008-09-10, released 2009-03-31
The last revision was dated 2012-04-18, with a file datestamp of 2012-04-13.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.21
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Trimethylguanosine synthase homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TGS1, HCA137, NCOA6IP, PIMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RS0 (5-End)
      • expression tag (1-4)
  • Chain 'B':
    Compound: Trimethylguanosine synthase homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TGS1, HCA137, NCOA6IP, PIMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RS0 (5-End)
      • expression tag (1-4)
  • Chain 'C':
    Compound: Trimethylguanosine synthase homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TGS1, HCA137, NCOA6IP, PIMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RS0 (5-End)
      • expression tag (1-4)
  • Chain 'D':
    Compound: Trimethylguanosine synthase homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TGS1, HCA137, NCOA6IP, PIMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96RS0 (5-End)
      • expression tag (1-4)
  • Heterogens: ADP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3egiA (A:)
gplgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiq
faltgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwg
gpdyataetfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveie
qnflnnklktitayfgdlirrpaset

    Sequence, based on observed residues (ATOM records):
    >3egiA (A:)
plgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiqf
altgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwat
aetfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveieqnflnn
klktitayfgdlirr

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3egiB (B:)
gplgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiq
faltgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwg
gpdyataetfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveie
qnflnnklktitayfgdlirrpaset

    Sequence, based on observed residues (ATOM records):
    >3egiB (B:)
plgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiqf
altgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwae
tfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveieqnflnnkl
ktitayfgdlir

  • Chain 'C':
    Sequence, based on SEQRES records:
    >3egiC (C:)
gplgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiq
faltgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwg
gpdyataetfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveie
qnflnnklktitayfgdlirrpaset

    Sequence, based on observed residues (ATOM records):
    >3egiC (C:)
plgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiqf
altgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwae
tfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveieqnflnnkl
ktitayfgdlir

  • Chain 'D':
    Sequence, based on SEQRES records:
    >3egiD (D:)
gplgsrlfsrfddgikldregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiq
faltgmrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwg
gpdyataetfdirtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveie
qnflnnklktitayfgdlirrpaset

    Sequence, based on observed residues (ATOM records):
    >3egiD (D:)
plgsrlfsrfddgregwfsvtpekiaehiagrvsqsfkcdvvvdafcgvggntiqfaltg
mrviaididpvkialarnnaevygiadkieficgdflllasflkadvvflsppwgaetfd
irtmmspdgfeifrlskkitnnivyflprnadidqvaslagpggqveieqnflnnklkti
tayfgdlir