PDB entry 3efl

View 3efl on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with motesanib
Class: transferase
Keywords: angiogenesis, motesanib, nicotinamide, receptor tyrosine kinase, Transferase
Deposited on 2008-09-09, released 2009-09-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-23, with a file datestamp of 2017-08-18.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (125-306)
      • engineered mutation (2)
      • engineered mutation (125)
      • expression tag (307-313)
    Domains in SCOPe 2.08: d3efla1, d3efla2
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3eflb_
  • Heterogens: 706, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3eflA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3eflA (A:)
aerlpydaskwefprdrlklgkplgrggqvieadafgidtcrtvavkmlkethsehralm
selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykvape
dlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfgplkwm
apetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdytt
pemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3eflB (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3eflB (B:)
pydaskwefprdrlklgkplgrggqvieadafgidktatcrtvavkmlathsehralmse
lkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykfltleh
licysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmapetifdrvy
tiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldc
whgepsqrptfselvehlgnllq