PDB entry 3ed7

View 3ed7 on RCSB PDB site
Description: Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Class: transferase
Keywords: TRANSFERASE, Methyltransferase, Nucleotide biosynthesis
Deposited on 2008-09-02, released 2010-03-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-24, with a file datestamp of 2019-07-19.
Experiment type: XRAY
Resolution: 1.56 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: OK/SW-cl.29, TS, TYMS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered (2)
    Domains in SCOPe 2.08: d3ed7a_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ed7A (A:)
mplxxxxpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkr
vfwkgvleellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfq
wrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchal
cqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiy
lnhieplkiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >3ed7A (A:)
lxxxxpphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvf
wkgvleellwfikgstnakelsswdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptikm