PDB entry 3e8a
View 3e8a on RCSB PDB site
Description: Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(l-Thiophosphate) and Low Ca Concentration
Class: lyase/lyase inhibitor
Keywords: ADENYLYL CYCLASE, G(S)ALPHA, ATP-ALPHAS, Alternative splicing, cAMP biosynthesis, Glycoprotein, Lyase, Magnesium, Membrane, Metal-binding, Phosphoprotein, Transmembrane, Cell membrane, GTP-binding, Lipoprotein, Nucleotide-binding, Palmitate, Transducer, LYASE-LYASE INHIBITOR COMPLEX
Deposited on
2008-08-19, released
2009-05-12
The last revision prior to the SCOPe 2.07 freeze date was dated
2010-04-07, with a file datestamp of
2010-04-02.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.242
AEROSPACI score: 0.15
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Adenylate cyclase type 5
Species: Canis lupus familiaris [TaxId:9615]
Gene: ADCY5, Adenylyl cyclase Type V
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3e8aa_ - Chain 'B':
Compound: Adenylate cyclase type 2
Species: Rattus norvegicus [TaxId:10116]
Gene: Adcy2, Adenylyl cyclase Type II
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3e8ab_ - Chain 'C':
Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Species: Bos taurus [TaxId:9913]
Gene: GNAS, GNAS1
Database cross-references and differences (RAF-indexed):
- Heterogens: FKP, CA, AGS, MG, GSP, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3e8aA (A:)
mhhhhhhamemkadinakqedmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmt
lnelfarfdklaaenhclrikilgdcyycvsglpearadhahccvemgmdmieaislvre
mtgvnvnmrvgihsgrvhcgvlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsy
lngdyevepgcggernaylkehsietflilrctqkrkeekamiak
Sequence, based on observed residues (ATOM records): (download)
>3e8aA (A:)
dmmfhkiyiqkhdnvsilfadiegftslasqctaqelvmtlnelfarfdklaaenhclri
kilgdcyycvsglpearadhahccvemgmdmieaislvremtgvnvnmrvgihsgrvhcg
vlglrkwqfdvwsndvtlanhmeaggkagrihitkatlsylngdyevepgcggernaylk
ehsietflil
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3e8aB (B:)
rslkneelyhqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskp
kfsgvekiktigstymaatglsaipsqehaqeperqymhigtmvefayalvgkldainkh
sfndfklrvginhgpviagvigaqkpqydiwgntvnvasrmdstgvldkiqvteetslil
qtlgytctcrgiinvkgkgdlktyfvntemsr
Sequence, based on observed residues (ATOM records): (download)
>3e8aB (B:)
hqsydcvcvmfasipdfkefytesdvnkegleclrllneiiadfddllskpkfsgvekik
tigstymaatglsarqymhigtmvefayalvgkldainkhsfndfklrvginhgpviagv
igaqkpqydiwgntvnvasrmdstgvldkiqvteetslilqtlgytctcrgiinvkgkgd
lktyfvnt
- Chain 'C':
No sequence available.