PDB entry 3e7g

View 3e7g on RCSB PDB site
Description: Structure of human INOSOX with inhibitor AR-C95791
Class: oxidoreductase
Keywords: nitric oxide, NOS, HEME, tetrahydrobiopterin, oxidoreductase, Alternative splicing, Calcium, Calmodulin-binding, FAD, FMN, Iron, Metal-binding, NADP, Phosphoprotein, Polymorphism, Zinc
Deposited on 2008-08-18, released 2008-10-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-01-20, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.182
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nitric oxide synthase, inducible
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3e7ga_
  • Chain 'B':
    Compound: Nitric oxide synthase, inducible
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3e7gb_
  • Chain 'C':
    Compound: Nitric oxide synthase, inducible
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3e7gc_
  • Chain 'D':
    Compound: Nitric oxide synthase, inducible
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3e7gd_
  • Heterogens: ZN, HEM, H4B, AT2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e7gA (A:)
prhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellp
qaiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprci
griqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwn
aqliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfei
ppdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvr
dfcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaae
sfmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvw
qdek

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7gA (A:)
rhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellpq
aiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprcig
riqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwna
qliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfeip
pdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvrd
fcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaaes
fmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvwq
d

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e7gB (B:)
prhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellp
qaiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprci
griqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwn
aqliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfei
ppdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvr
dfcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaae
sfmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvw
qdek

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7gB (B:)
rhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellpq
aiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprcig
riqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwna
qliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfeip
pdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvrd
fcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaaes
fmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvwq
d

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3e7gC (C:)
prhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellp
qaiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprci
griqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwn
aqliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfei
ppdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvr
dfcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaae
sfmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvw
qdek

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7gC (C:)
rhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellpq
aiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprcig
riqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwna
qliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfeip
pdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvrd
fcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaaes
fmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvwq
dek

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3e7gD (D:)
prhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellp
qaiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprci
griqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwn
aqliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfei
ppdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvr
dfcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaae
sfmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvw
qdek

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7gD (D:)
rhvriknwgsgmtfqdtlhhkakgiltcrsksclgsimtpksltrgprdkptppdellpq
aiefvnqyygsfkeakieehlarveavtkeiettgtyqltgdelifatkqawrnaprcig
riqwsnlqvfdarscstaremfehicrhvrystnngnirsaitvfpqrsdgkhdfrvwna
qliryagyqmpdgsirgdpanveftqlcidlgwkpkygrfdvvplvlqangrdpelfeip
pdlvlevamehpkyewfrelelkwyalpavanmllevgglefpgcpfngwymgteigvrd
fcdvqrynileevgrrmglethklaslwkdqavveiniavlhsfqkqnvtimdhhsaaes
fmkymqneyrsrggcpadwiwlvppmsgsitpvfhqemlnyvlspfyyyqveawkthvwq
d