PDB entry 3e7c

View 3e7c on RCSB PDB site
Description: Glucocorticoid Receptor LBD bound to GSK866
Class: transcription
Keywords: GR, Glucocorticoid Receptor, Nuclear Receptor, Alternative initiation, Chromatin regulator, Disease mutation, DNA-binding, Lipid-binding, Metal-binding, Nucleus, Phosphoprotein, Pseudohermaphroditism, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc-finger, Activator
Deposited on 2008-08-18, released 2008-11-25
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.21
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C1, GRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (81)
      • engineered (117)
    Domains in SCOPe 2.01: d3e7ca_
  • Chain 'B':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C1, GRL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered (81)
      • engineered (117)
    Domains in SCOPe 2.01: d3e7cb_
  • Chain 'D':
    Compound: nuclear receptor coactivator 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: nuclear receptor coactivator 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 866, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e7cA (A:)
vpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwaka
ipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpgmy
dqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgka
ivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnq
ipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7cA (A:)
pqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgfr
nlhlddqmtllqyswmylmafalgwrsyrqnllcfapdliineqrmtlpgmydqckhmly
vsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregns
sqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngn
ikkllfhq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e7cB (B:)
vpatlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwaka
ipgfrnlhlddqmtllqyswmylmafalgwrsyrqssanllcfapdliineqrmtlpgmy
dqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgka
ivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnq
ipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >3e7cB (B:)
lpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqviaavkwakaipgf
rnlhlddqmtllqyswmylmafalgwrsyrqanllcfapdliineqrmtlpgmydqckhm
lyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivksqn
wqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikk
llfhq

  • Chain 'D':
    No sequence available.

  • Chain 'H':
    No sequence available.