PDB entry 3e6i

View 3e6i on RCSB PDB site
Description: Human cytochrome P450 2E1 in complex with the inhibitor indazole
Deposited on 2008-08-15, released 2008-09-23
The last revision was dated 2009-06-09, with a file datestamp of 2009-06-05.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.223
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2E1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2E1, CYP2E
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05181 (10-471)
      • expression tag (9)
  • Chain 'B':
    Compound: Cytochrome P450 2E1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2E1, CYP2E
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05181 (10-471)
      • expression tag (9)
  • Heterogens: HEM, LZ1, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3e6iA (A:)
makktsskgklppgpfplpiignlfqlelknipksftrlaqrfgpvftlyvgsqrmvvmh
gykavkealldykdefsgrgdlpafhahrdrgiifnngptwkdirrfslttlrnygmgkq
gnesriqreahfllealrktqgqpfdptfligcapcnviadilfrkhfdyndekflrlmy
lfnenfhllstpwlqlynnfpsflhylpgshrkviknvaevkeyvservkehhqsldpnc
prdltdcllvemekekhsaerlytmdgitvtvadlffagtettsttlrygllilmkypei
eeklheeidrvigpsripaikdrqempymdavvheiqrfitlvpsnlpheatrdtifrgy
lipkgtvvvptldsvlydnqefpdpekfkpehflnengkfkysdyfkpfstgkrvcageg
larmelflllcailqhfnlkplvdpkdidlspihigfgcippryklcviprshhhh

    Sequence, based on observed residues (ATOM records):
    >3e6iA (A:)
klppgpfplpiignlfqlelknipksftrlaqrfgpvftlyvgsqrmvvmhgykavkeal
ldykdefsgrgdlpafhahrdrgiifnngptwkdirrfslttlrnyggkqgnesriqrea
hfllealrktqgqpfdptfligcapcnviadilfrkhfdyndekflrlmylfnenfhlls
tpwlqlynnfpsflhylpgshrkviknvaevkeyvservkehhqsldpncprdltdcllv
emekekhsaerlytmdgitvtvadlffagtettsttlrygllilmkypeieeklheeidr
vigpsripaikdrqempymdavvheiqrfitlvpsnlpheatrdtifrgylipkgtvvvp
tldsvlydnqefpdpekfkpehflnengkfkysdyfkpfstgkrvcageglarmelflll
cailqhfnlkplvdpkdidlspihigfgcippryklcviprs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3e6iB (B:)
makktsskgklppgpfplpiignlfqlelknipksftrlaqrfgpvftlyvgsqrmvvmh
gykavkealldykdefsgrgdlpafhahrdrgiifnngptwkdirrfslttlrnygmgkq
gnesriqreahfllealrktqgqpfdptfligcapcnviadilfrkhfdyndekflrlmy
lfnenfhllstpwlqlynnfpsflhylpgshrkviknvaevkeyvservkehhqsldpnc
prdltdcllvemekekhsaerlytmdgitvtvadlffagtettsttlrygllilmkypei
eeklheeidrvigpsripaikdrqempymdavvheiqrfitlvpsnlpheatrdtifrgy
lipkgtvvvptldsvlydnqefpdpekfkpehflnengkfkysdyfkpfstgkrvcageg
larmelflllcailqhfnlkplvdpkdidlspihigfgcippryklcviprshhhh

    Sequence, based on observed residues (ATOM records):
    >3e6iB (B:)
klppgpfplpiignlfqlelknipksftrlaqrfgpvftlyvgsqrmvvmhgykavkeal
ldykdefsgrgdlpafhahrdrgiifnngptwkdirrfslttlrnygkqgnesriqreah
fllealrktqgqpfdptfligcapcnviadilfrkhfdyndekflrlmylfnenfhllst
pwlqlynnfpsflhylpgshrkviknvaevkeyvservkehhqsldpncprdltdcllve
mekekhsaerlytmdgitvtvadlffagtettsttlrygllilmkypeieeklheeidrv
igpsripaikdrqempymdavvheiqrfitlvpsnlpheatrdtifrgylipkgtvvvpt
ldsvlydnqefpdpekfkpehflnengkfkysdyfkpfstgkrvcageglarmelflllc
ailqhfnlkplvdpkdidlspihigfgcippryklcviprs