PDB entry 3e63

View 3e63 on RCSB PDB site
Description: Fragment based discovery of JAK-2 inhibitors
Class: transferase
Keywords: DRUG DISCOVERY, JAK2, FRAGMENT BASED, ATP-binding, Disease mutation, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2008-08-14, released 2008-10-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-02-08, with a file datestamp of 2012-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.203
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3e63a_
  • Heterogens: 5B2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e63A (A:)
rdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfere
ieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqyts
qickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespi
fwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhl
iellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma

    Sequence, based on observed residues (ATOM records): (download) 
    >3e63A (A:)
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma