PDB entry 3e4a

View 3e4a on RCSB PDB site
Description: human ide-inhibitor complex at 2.6 angstrom resolution
Deposited on 2008-08-11, released 2009-05-19
The last revision was dated 2021-10-20, with a file datestamp of 2021-10-15.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735 (0-1018)
      • engineered mutation (77)
      • engineered mutation (109-110)
      • engineered mutation (170)
      • engineered mutation (177)
      • engineered mutation (256)
      • engineered mutation (413)
      • engineered mutation (554)
      • engineered mutation (566-568)
      • engineered mutation (572)
      • engineered mutation (589)
      • engineered mutation (788)
      • engineered mutation (811)
      • engineered mutation (818)
      • engineered mutation (844)
      • engineered mutation (903)
      • engineered mutation (965)
      • engineered mutation (973)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735 (0-1018)
      • engineered mutation (77)
      • engineered mutation (109-110)
      • engineered mutation (170)
      • engineered mutation (177)
      • engineered mutation (256)
      • engineered mutation (413)
      • engineered mutation (554)
      • engineered mutation (566-568)
      • engineered mutation (572)
      • engineered mutation (589)
      • engineered mutation (788)
      • engineered mutation (811)
      • engineered mutation (818)
      • engineered mutation (844)
      • engineered mutation (903)
      • engineered mutation (965)
      • engineered mutation (973)
  • Chain 'F':
    Compound: hydroxamate peptide ii1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 3E4A (0-2)
  • Chain 'G':
    Compound: hydroxamate peptide ii1
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 3E4A (0-2)
  • Heterogens: ZN, QIX, DIO, ACY, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >3e4aA (A:)
mryrlawllhpalpstfrsvlgarlppperlcgfqkktyskmnnpaikrignhitksped
kreyrglelangikvllisdpttdkssaaldvhigslsdppniaglshflqhmlflgtkk
ypkeneysqflsehagssnaftsgehtnyyfdvshehlegaldrfaqfflsplfdesakd
revnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnkytletrpnqegidvrqe
llkfhsayyssnlmavvvlgreslddltnlvvklfsevenknvplpefpehpfqeehlkq
lykivpikdirnlyvtfpipdlqkyyksnpghylghlighegpgsllselkskgwvntlv
ggqkegargfmffiinvdlteegllhvediilhmfqyiqklraegpqewvfqelkdlnav
afrfkdkerprgytskiagilhyypleevltaeylleefrpdliemvldklrpenvrvai
vsksfegktdrteewygtqykqeaipdevikkwqnadlngkfklptknefiptnfeilpl
ekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfayvdplhsnmaylylell
kdslneyayaaelaglsydlqntiygmylsvkgyndkqpillkkiiekmatfeidekrfe
iikeaymrslnnfraeqphqhamyylrllmtevawtkdelkealddvtlprlkafipqll
srlhieallhgnitkqaalgimqmvedtliehahtkpllpsqlvryrevqlpdrgwfvyq
qrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntlrtkeqlgyivfsgprra
ngiqglrfiiqsekpphylesrveaflitmeksiedmteeafqkhiqalairrldkpkkl
saesakywgeiisqqynfdrdntevaylktltkediikfykemlavdaprrhkvsvhvla
remdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >3e4aA (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnpvvgnlsqapalpqpeviqnmtefkrglplfplvkp
h

  • Chain 'B':
    Sequence, based on SEQRES records:
    >3e4aB (B:)
mryrlawllhpalpstfrsvlgarlppperlcgfqkktyskmnnpaikrignhitksped
kreyrglelangikvllisdpttdkssaaldvhigslsdppniaglshflqhmlflgtkk
ypkeneysqflsehagssnaftsgehtnyyfdvshehlegaldrfaqfflsplfdesakd
revnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnkytletrpnqegidvrqe
llkfhsayyssnlmavvvlgreslddltnlvvklfsevenknvplpefpehpfqeehlkq
lykivpikdirnlyvtfpipdlqkyyksnpghylghlighegpgsllselkskgwvntlv
ggqkegargfmffiinvdlteegllhvediilhmfqyiqklraegpqewvfqelkdlnav
afrfkdkerprgytskiagilhyypleevltaeylleefrpdliemvldklrpenvrvai
vsksfegktdrteewygtqykqeaipdevikkwqnadlngkfklptknefiptnfeilpl
ekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfayvdplhsnmaylylell
kdslneyayaaelaglsydlqntiygmylsvkgyndkqpillkkiiekmatfeidekrfe
iikeaymrslnnfraeqphqhamyylrllmtevawtkdelkealddvtlprlkafipqll
srlhieallhgnitkqaalgimqmvedtliehahtkpllpsqlvryrevqlpdrgwfvyq
qrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntlrtkeqlgyivfsgprra
ngiqglrfiiqsekpphylesrveaflitmeksiedmteeafqkhiqalairrldkpkkl
saesakywgeiisqqynfdrdntevaylktltkediikfykemlavdaprrhkvsvhvla
remdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrglplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >3e4aB (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnpvvgnlsqapalpqpeviqnmtefkrglplfplvkp
h

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >3e4aF (F:)
aaa

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records:
    >3e4aG (G:)
aaa