PDB entry 3e37

View 3e37 on RCSB PDB site
Description: Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5
Class: Transferase
Keywords: FTase, farnesyltransferase, protein farnesyltransferase, malaria, plasmodium, falciparum, ethylenediamine, Prenyltransferase, Transferase, Metal-binding, Phosphoprotein, Zinc
Deposited on 2008-08-06, released 2009-03-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-03-10, with a file datestamp of 2009-03-06.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.169
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3e37a_
  • Chain 'B':
    Compound: Protein farnesyltransferase subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: Fntb
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3e37b_
  • Heterogens: ZN, ED5, SUC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e37A (A:)
maategvgeaaqggepgqpaqpppqphppppqqqhkeemaaeageavaspmddgfvslds
psyvlyrdraewadidpvpqndgpnpvvqiiysdkfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllkslqkdlheemnyitaiieeqpknyqvwhhrrvlvewlr
dpsqelefiadilnqdaknyhawqhrqwviqefklwdnelqyvdqllkedvrnnsvwnqr
yfvisnttgyndravlerevqytlemiklvphnesawnylkgilqdrglskypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhstendsptnvqq

    Sequence, based on observed residues (ATOM records): (download) 
    >3e37A (A:)
fvsldspsyvlyrdraewadidpvpqndgpnpvvqiiysdkfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllkslqkdlheemnyitaiieeqpknyqvwhhrrv
lvewlrdpsqelefiadilnqdaknyhawqhrqwviqefklwdnelqyvdqllkedvrnn
svwnqryfvisnttgyndravlerevqytlemiklvphnesawnylkgilqdrglskypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhst

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e37B (B:)
maspssftyycppssspvwseplyslrpeharerlqddsvetvtsieqakveekiqevfs
sykfnhlvprlvlqrekhfhylkrglrqltdayecldasrpwlcywilhslelldepipq
ivatdvcqflelcqspeggfgggpgqyphlaptyaavnalciigteeaydiinrekllqy
lyslkqpdgsflmhvggevdvrsaycaasvasltniitpdlfegtaewiarcqnweggig
gvpgmeahggytfcglaalvilkrerslnlksllqwvtsrqmrfeggfqgrcnklvdgcy
sfwqagllpllhralhaqgdpalsmshwmfhqqalqeyilmccqcpagglldkpgksrdf
yhtcyclsglsiaqhfgsgamlhdvvlgvpenalqpthpvynigpdkviqattyflqkpv
pgfeelkdetsaepatd

    Sequence, based on observed residues (ATOM records): (download) 
    >3e37B (B:)
sspvwseplyslrpeharerlqddsvetvtsieqakveekiqevfssykfnhlvprlvlq
rekhfhylkrglrqltdayecldasrpwlcywilhslelldepipqivatdvcqflelcq
speggfgggpgqyphlaptyaavnalciigteeaydiinrekllqylyslkqpdgsflmh
vggevdvrsaycaasvasltniitpdlfegtaewiarcqnweggiggvpgmeahggytfc
glaalvilkrerslnlksllqwvtsrqmrfeggfqgrcnklvdgcysfwqagllpllhra
lhaqgdpalsmshwmfhqqalqeyilmccqcpagglldkpgksrdfyhtcyclsglsiaq
hfgsgamlhdvvlgvpenalqpthpvynigpdkviqattyflqkpvpgfe