PDB entry 3e0n

View 3e0n on RCSB PDB site
Description: The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor
Class: hydrolase
Keywords: PROSTASIN, PROTEASE, chloromethyl-ketone, Channel, ENaC, Cell membrane, Glycoprotein, Hydrolase, Membrane, Secreted, Serine protease, Transmembrane, Zymogen
Deposited on 2008-07-31, released 2009-06-16
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.159
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Prostasin
    Species: Homo sapiens [TaxId:9606]
    Gene: PRSS8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16651 (0-End)
      • engineered (109)
      • engineered (114)
      • engineered (158)
    Domains in SCOPe 2.05: d3e0nb_
  • Heterogens: SO4, DPN, GOL, HOH

PDB Chain Sequences:

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e0nB (B:)
itggssavagqwpwqvsityegvhvcggslvseqwvlsaahcfpsehhkeayevklgahq
ldsysedakvstlkdiiphpsylqegsqgdiallqlsrpitfsryirpislpaaqasfpn
glhctvtgwghvapsvslltpkplqqlevplisretcnslynidakpeephfvqedmvca
gyveggkdacqgdsggplscpveglwyltgivswgdacgarnrpgvytlassyaswiqsk
vtelqprvvpqtqesqpdsnlhhhhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3e0nB (B:)
itggssavagqwpwqvsityegvhvcggslvseqwvlsaahcfpsehhkeayevklgahq
ldsysedakvstlkdiiphpsylqegsqgdiallqlsrpitfsryirpislpaaqasfpn
glhctvtgwghvapsvslltpkplqqlevplisretcnslynidakpeephfvqedmvca
gyveggkdacqgdsggplscpveglwyltgivswgdacgarnrpgvytlassyaswiqsk
vtelqprvvpq