PDB entry 3e04

View 3e04 on RCSB PDB site
Description: Crystal structure of human fumarate hydratase
Class: lyase
Keywords: fumarase, TCA cycle, Structural Genomics Consortium, Alternative initiation, Anti-oncogene, Cell cycle, Disease mutation, Lyase, Mitochondrion, Transit peptide, Tricarboxylic acid cycle, SGC
Deposited on 2008-07-30, released 2008-08-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fumarate hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: FH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3e04a_
  • Chain 'B':
    Compound: Fumarate hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: FH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3e04b_
  • Chain 'C':
    Compound: Fumarate hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: FH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3e04c_
  • Chain 'D':
    Compound: Fumarate hydratase
    Species: Homo sapiens [TaxId:9606]
    Gene: FH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3e04d_
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3e04A (A:)
mhhhhhhssgvdlgtenlyfqsmmasqnsfrieydtfgelkvpndkyygaqtvrstmnfk
iggvtermptpvikafgilkraaaevnqdygldpkianaimkaadevaegklndhfplvv
wqtgsgtqtnmnvnevisnraiemlggelgskipvhpndhvnksqssndtfptamhiaaa
ievhevllpglqklhdaldakskefaqiikigrthtqdavpltlgqefsgyvqqvkyamt
rikaampriyelaaggtavgtglntrigfaekvaakvaaltglpfvtapnkfealaahda
lvelsgamnttacslmkiandirflgsgprsglgelilpenepgssimpgkvnptqceam
tmvaaqvmgnhvavtvggsnghfelnvfkpmmiknvlhsarllgdasvsftencvvgiqa
nterinklmneslmlvtalnphigydkaakiaktahkngstlketaielgyltaeqfdew
vkpkdmlgpk

    Sequence, based on observed residues (ATOM records): (download) 
    >3e04A (A:)
sfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaaevnq
dygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiemlgge
lgskipvhpndhvnksqssndtfptamhiaaaievhevllpglqklhdaldakskefaqi
ikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtglntrig
faekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirflgsg
prsglgelilpenepggkvnptqceamtmvaaqvmgnhvavtvggsnghfelnvfkpmmi
knvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphigydkaakiak
tahkngstlketaielgyltaeqfdewvkpkdmlgp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3e04B (B:)
mhhhhhhssgvdlgtenlyfqsmmasqnsfrieydtfgelkvpndkyygaqtvrstmnfk
iggvtermptpvikafgilkraaaevnqdygldpkianaimkaadevaegklndhfplvv
wqtgsgtqtnmnvnevisnraiemlggelgskipvhpndhvnksqssndtfptamhiaaa
ievhevllpglqklhdaldakskefaqiikigrthtqdavpltlgqefsgyvqqvkyamt
rikaampriyelaaggtavgtglntrigfaekvaakvaaltglpfvtapnkfealaahda
lvelsgamnttacslmkiandirflgsgprsglgelilpenepgssimpgkvnptqceam
tmvaaqvmgnhvavtvggsnghfelnvfkpmmiknvlhsarllgdasvsftencvvgiqa
nterinklmneslmlvtalnphigydkaakiaktahkngstlketaielgyltaeqfdew
vkpkdmlgpk

    Sequence, based on observed residues (ATOM records): (download) 
    >3e04B (B:)
sfrieyelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaaevnqdygl
dpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiemlggelgsk
ipvhpndhvnksqssndtfptamhiaaaievhevllpglqklhdaldakskefaqiikig
rthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtglntrigfaek
vaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirflgsgprsg
lgelilpenepgssimpgkvnptqceamtmvaaqvmgnhvavtvggsnghfelnvfkpmm
iknvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphigakiaktah
kngstlketaielgyltaeqfdewvkpkdmlgpk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3e04C (C:)
mhhhhhhssgvdlgtenlyfqsmmasqnsfrieydtfgelkvpndkyygaqtvrstmnfk
iggvtermptpvikafgilkraaaevnqdygldpkianaimkaadevaegklndhfplvv
wqtgsgtqtnmnvnevisnraiemlggelgskipvhpndhvnksqssndtfptamhiaaa
ievhevllpglqklhdaldakskefaqiikigrthtqdavpltlgqefsgyvqqvkyamt
rikaampriyelaaggtavgtglntrigfaekvaakvaaltglpfvtapnkfealaahda
lvelsgamnttacslmkiandirflgsgprsglgelilpenepgssimpgkvnptqceam
tmvaaqvmgnhvavtvggsnghfelnvfkpmmiknvlhsarllgdasvsftencvvgiqa
nterinklmneslmlvtalnphigydkaakiaktahkngstlketaielgyltaeqfdew
vkpkdmlgpk

    Sequence, based on observed residues (ATOM records): (download) 
    >3e04C (C:)
sfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaaevnq
dygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiemlgge
lgskipvhpndhvnksqssndtfptamhiaaaievhevllpglqklhdaldakskefaqi
ikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtglntrig
faekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirflgsg
prsglgelilpenepgssimpgkvnptqceamtmvaaqvmgnhvavtvggsnghfelnvf
kpmmiknvlhsarllgdasvsftencvvgiqanterinklmneslmkpkdmlgpk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3e04D (D:)
mhhhhhhssgvdlgtenlyfqsmmasqnsfrieydtfgelkvpndkyygaqtvrstmnfk
iggvtermptpvikafgilkraaaevnqdygldpkianaimkaadevaegklndhfplvv
wqtgsgtqtnmnvnevisnraiemlggelgskipvhpndhvnksqssndtfptamhiaaa
ievhevllpglqklhdaldakskefaqiikigrthtqdavpltlgqefsgyvqqvkyamt
rikaampriyelaaggtavgtglntrigfaekvaakvaaltglpfvtapnkfealaahda
lvelsgamnttacslmkiandirflgsgprsglgelilpenepgssimpgkvnptqceam
tmvaaqvmgnhvavtvggsnghfelnvfkpmmiknvlhsarllgdasvsftencvvgiqa
nterinklmneslmlvtalnphigydkaakiaktahkngstlketaielgyltaeqfdew
vkpkdmlgpk

    Sequence, based on observed residues (ATOM records): (download) 
    >3e04D (D:)
sfrieydtfgelkvpndkyygaqtvrstmnfkiggvtermptpvikafgilkraaaevnq
dygldpkianaimkaadevaegklndhfplvvwqtgsgtqtnmnvnevisnraiemlgge
lgskipvhpndhvnksqssndtfptamhiaaaievhevllpglqklhdaldakskefaqi
ikigrthtqdavpltlgqefsgyvqqvkyamtrikaampriyelaaggtavgtglntrig
faekvaakvaaltglpfvtapnkfealaahdalvelsgamnttacslmkiandirflgsg
prsglgelilpenepgmpgkvnptqceamtmvaaqvmgnhvavtvggsnghfelnvfkpm
miknvlhsarllgdasvsftencvvgiqanterinklmneslmlvtalnphigydkaaki
aktahkngstlketaielgyltaeqfdewvkpkdmlgpk