PDB entry 3dzj

View 3dzj on RCSB PDB site
Description: Crystal structure of human CD38 extracellular domain E226Q mutant, NMN complex
Class: hydrolase
Keywords: NMN complex, E226Q mutant, BETA SHEETS, ALPHA BUNDLE, Alternative splicing, Diabetes mellitus, Glycoprotein, Hydrolase, Membrane, NAD, Polymorphism, Receptor, Signal-anchor, Transmembrane
Deposited on 2008-07-29, released 2008-11-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.188
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • engineered (10)
      • engineered (61)
      • engineered (125)
      • engineered (170)
      • engineered (180)
      • engineered (187)
    Domains in SCOPe 2.07: d3dzja_
  • Chain 'B':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • engineered (10)
      • engineered (61)
      • engineered (125)
      • engineered (170)
      • engineered (180)
      • engineered (187)
    Domains in SCOPe 2.07: d3dzjb_
  • Heterogens: NMN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dzjA (A:)
kreaearwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhp
cditeedyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdlt
wcgefatskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdk
dstfgsvqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckni
yrpdkflqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >3dzjA (A:)
rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefa
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
lqcvknpedssc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dzjB (B:)
kreaearwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhp
cditeedyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdlt
wcgefatskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdk
dstfgsvqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckni
yrpdkflqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >3dzjB (B:)
rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefa
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
lqcvknpedssc