PDB entry 3dy7

View 3dy7 on RCSB PDB site
Description: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Class: transferase
Keywords: dual specificity protein kinase, non-ATP-competitive kinase inhibitor, inhibitor-bound protein kinase, ATP-bound protein kinase, Acetylation, ATP-binding, Disease mutation, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Deposited on 2008-07-25, released 2009-06-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-06-16, with a file datestamp of 2009-06-12.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.248
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dy7a_
  • Heterogens: MG, ATP, 1CX

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dy7A (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssy
gmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhaf
ikrsdaeevdfagwlcstiglnqpstpthaagvlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dy7A (A:)
elkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhec
nspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltylr
ekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmangtrsymsperlqgthysvqs
diwsmglslvemavgrypippppmaifelldyivnepppklpsgvfslefqdfvnkclik
npaeradlkqlmvhafikrs