PDB entry 3dxe
View 3dxe on RCSB PDB site
Description: Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2
Class: protein binding
Keywords: Alzheimer's disease, APP, AICD, Fe65, PTB domain, Alternative splicing, Polymorphism, Alzheimer disease, Amyloid, Apoptosis, Cell adhesion, Coated pit, Copper, Disease mutation, Endocytosis, Glycoprotein, Heparin-binding, Iron, Membrane, Metal-binding, Notch signaling pathway, Phosphoprotein, Protease inhibitor, Proteoglycan, Serine protease inhibitor, Transmembrane, Zinc, PROTEIN BINDING
Deposited on
2008-07-24, released
2008-09-16
The last revision prior to the SCOPe 2.01 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.208
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Amyloid beta A4 protein-binding family B member 1
Species: Homo sapiens [TaxId:9606]
Gene: APBB1, FE65, RIR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3dxea_ - Chain 'B':
Compound: amyloid beta a4 protein
Species: Homo sapiens [TaxId:9606]
Gene: APP, A4, AD1
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: Amyloid beta A4 protein-binding family B member 1
Species: Homo sapiens [TaxId:9606]
Gene: APBB1, FE65, RIR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.01: d3dxec_ - Chain 'D':
Compound: amyloid beta a4 protein
Species: Homo sapiens [TaxId:9606]
Gene: APP, A4, AD1
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3dxeA (A:)
apknelvqkfqvyylgnvpvakpvgvdvingalesvlssssreqwtpshvsvapatltil
hqqteavlgecrvrflsflavgrdvhtfafimaagpasfcchmfwcepnaaslseavqaa
cmlryqkcldarsqhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3dxeA (A:)
fqvyylgnvpvakpvgvdvingalesvlssssreqwtpshvsvapatltilhqqteavlg
ecrvrflsflavgrdvhtfafimaagpasfcchmfwcepnaaslseavqaacmlryqkcl
dars
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>3dxeC (C:)
apknelvqkfqvyylgnvpvakpvgvdvingalesvlssssreqwtpshvsvapatltil
hqqteavlgecrvrflsflavgrdvhtfafimaagpasfcchmfwcepnaaslseavqaa
cmlryqkcldarsqhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3dxeC (C:)
nelvqkfqvyylgnvpvakpvgvdvingalesvlssssreqwtpshvsvapatltilhqq
teavlgecrvrflsflavgrdvhtfafimaagpasfcchmfwcepnaaslseavqaacml
ryqkcldars
- Chain 'D':
No sequence available.