PDB entry 3dtw

View 3dtw on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a benzisoxazole inhibitor
Class: transferase
Keywords: angiogenesis, receptor tyrosine kinase, Transferase
Deposited on 2008-07-16, released 2008-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-23, with a file datestamp of 2017-08-18.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
    • Uniprot P35968 (125-306)
      • engineered (125)
      • expression tag (307-313)
    Domains in SCOPe 2.08: d3dtwa1, d3dtwa2
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (101)
    • Uniprot P35968
    Domains in SCOPe 2.08: d3dtwb_
  • Heterogens: A96, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dtwA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dtwA (A:)
erlpydaskwefprdrlklgkplgrggqvieadafgidktcrtvavkmlkegathsehra
lmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykva
pedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdflplk
wmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdy
ttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dtwB (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dtwB (B:)
lpydaskwefprdrlklgkplgrgqvieadafgidktatcrtvavkmlathsehralmse
lkilihighhlnvvnllgactkpggplmvitefckfgnlstylrskrnefvpykykdflt
lehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglrlplkwmapeti
fdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyq
tmldcwhgepsqrptfselvehlgnllqa