PDB entry 3dtc

View 3dtc on RCSB PDB site
Description: Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16
Class: transferase
Keywords: mixed-lineage kinase, MLK family, MLK1 and MLK3 Subtype Selective inhibitors, Alternative splicing, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, SH3 domain, Transferase
Deposited on 2008-07-14, released 2009-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-03-31, with a file datestamp of 2009-03-27.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.218
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase kinase kinase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP3K9, MLK1, PRKE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P80192 (0-End)
      • engineered (176)
    Domains in SCOPe 2.08: d3dtca_
  • Heterogens: SO4, VIN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dtcA (A:)
lleidfaeltleeiigiggfgkvyrafwigdevavkaarhdpdedisqtienvrqeaklf
amlkhpniialrgvclkepnlclvmefarggplnrvlsgkrippdilvnwavqiargmny
lhdeaivpiihrdlkssnililqkvengdlsnkilkitdfglarewhrttkmsaagayaw
mapevirasmfskgsdvwsygvllwelltgevpfrgidglavaygvamnklalpipstcp
epfaklmedcwnpdphsrpsftnildqltti

    Sequence, based on observed residues (ATOM records): (download) 
    >3dtcA (A:)
lleidfaeltleeiigiggfgkvyrafwigdevavkaatienvrqeaklfamlkhpniia
lrgvclkelclvmefarggplnrvlsgkrippdilvnwavqiargmnylhdeaivpiihr
dlkssnililqkvengdlsnkilkitdfglgayawmapevirasmfskgsdvwsygvllw
elltgevpfrgidglavaygvamnklalpipstcpepfaklmedcwnpdphsrpsftnil
dqltt