PDB entry 3drm
View 3drm on RCSB PDB site
Description: 2.2 Angstrom Crystal Structure of Thr114Phe Alpha1-Antitrypsin
Class: Hydrolase inhibitor
Keywords: serpin, serine proteinase inhibitor, alpha1-antitrypsin, polymerisation, rational drug design, conformational disease, emphysema, cirrhosis, Acute phase, Alternative splicing, Blood coagulation, Disease mutation, Glycoprotein, Hydrolase, Polymorphism, Protease, Protease inhibitor, Secreted, Serine protease inhibitor, Hydrolase inhibitor
Deposited on
2008-07-11, released
2009-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-04-14, with a file datestamp of
2009-04-10.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.224
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: alpha-1-antitrypsin
Species: Homo sapiens [TaxId:9606]
Gene: SERPINA1, AAT, PI, PRO0684, PRO2209
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3drma_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3drmA (A:)
mrgshhhhhhtdpqgdaaqktdtshhdqdhptfnkitpnlaefafslyrqlahqsnstni
ffspvsiatafamlslgtkadthdeileglnfnlteipeaqihegfqellrtlnqpdsql
qltfgnglflseglklvdkfledvkklyhseaftvnfgdteeakkqindyvekgtqgkiv
dlvkeldrdtvfalvnyiffkgkwerpfevkdteeedfhvdqvttvkvpmmkrlgmfniq
hckklsswvllmkylgnataifflpdegklqhlenelthdiitkflenedrrsaslhlpk
lsitgtydlksvlgqlgitkvfsngadlsgvteeaplklskavhkavltidekgteaaga
mfleaipmsippevkfnkpfvflmieqntksplfmgkvvnptqk
Sequence, based on observed residues (ATOM records): (download)
>3drmA (A:)
nkitpnlaefafslyrqlahqsnstniffspvsiatafamlslgtkadthdeileglnfn
lteipeaqihegfqellrtlnqpdsqlqltfgnglflseglklvdkfledvkklyhseaf
tvnfgdteeakkqindyvekgtqgkivdlvkeldrdtvfalvnyiffkgkwerpfevkdt
eeedfhvdqvttvkvpmmkrlgmfniqhckklsswvllmkylgnataifflpdegklqhl
enelthdiitkflenedrrsaslhlpklsitgtydlksvlgqlgitkvfsngadlsgvte
eaplklskavhkavltidekfleaipmsippevkfnkpfvflmieqntksplfmgkvvnp
tq