PDB entry 3dpk

View 3dpk on RCSB PDB site
Description: cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
Class: transferase
Keywords: RECEPTOR TYROSINE KINASE, KINASE-INHIBITOR COMPLEX, ATP-binding, Glycoprotein, Immunoglobulin domain, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase, Craniosynostosis, Disease mutation, Dwarfism, Heparin-binding, Kallmann syndrome
Deposited on 2008-07-08, released 2009-02-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF1R, FGFBR, FGFR1, FLG, FLT2, FMS, BFGFR, CEK, HBGFR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dpka_
  • Heterogens: SO4, 8C5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dpkA (A:)
gvdykykqkpkyqvrwkiiesyegnsytfidptqlpynekwefprnnlqfgktlgagafg
kvveatafglgkedavlkvavkmlkstahadekealmselkimshlgqhenivnllgact
hggpvlviteyccygdllnflrrkrppgleysynpshnpeeqlssrdllhfssqvaqgma
flaskncihrdvaarnvlltnghvakigdfglardimndsnyivkgnarlpvkwmapesi
fdcvytvqsdvwsygillweifslglnpypgilvnskfyklvkdgyqmaqpafapkniys
imqacwalepthrptfqqicsflqeqaqedrrerd

    Sequence, based on observed residues (ATOM records): (download) 
    >3dpkA (A:)
vrwkiiessytfidpynekwefprnnlqfgktlgagafgkvveatafglgavlkvavkml
kstahadekealmselkimshlgqhenivnllgacthggpvlviteyccygdllnflrrq
lssrdllhfssqvaqgmaflaskncihrdvaarnvlltnghvakigdfglardimndsny
ivrlpvkwmapesifdcvytvqsdvwsygillweifslglnpypgilvnskfyklvkdgy
qmaqpafapkniysimqacwalepthrptfqqicsflqe