PDB entry 3dls

View 3dls on RCSB PDB site
Description: Crystal structure of human PAS kinase bound to ADP
Class: transferase
Keywords: PAS KINASE, PASK, PROTEIN KINASE, DRUG DISCOVERY, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Structural Genomics, PSI-2, Protein Structure Initiative, New York SGX Research Center for Structural Genomics, NYSGXRC
Deposited on 2008-06-29, released 2008-08-26
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-08-19, with a file datestamp of 2015-08-14.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: PAS domain-containing serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PASK, KIAA0135
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3dlsa_
  • Chain 'B':
    Compound: PAS domain-containing serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PASK, KIAA0135
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3dlsb_
  • Chain 'C':
    Compound: PAS domain-containing serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PASK, KIAA0135
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3dlsc_
  • Chain 'D':
    Compound: PAS domain-containing serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PASK, KIAA0135
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3dlsd_
  • Chain 'E':
    Compound: PAS domain-containing serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PASK, KIAA0135
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3dlse_
  • Chain 'F':
    Compound: PAS domain-containing serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: PASK, KIAA0135
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3dlsf_
  • Heterogens: MG, ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dlsA (A:)
maleeppkaveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikke
kvledcwiedpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfaf
idrhprldeplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaayl
ergklfytfcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaa
ihppylvskelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevfrvnkpes
gvlsaaslemgnrslsdvaqaqelcggeghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dlsA (A:)
aveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikkekvledcwi
edpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfafidrhprld
eplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaaylergklfyt
fcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaaihppylvs
kelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dlsB (B:)
maleeppkaveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikke
kvledcwiedpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfaf
idrhprldeplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaayl
ergklfytfcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaa
ihppylvskelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevfrvnkpes
gvlsaaslemgnrslsdvaqaqelcggeghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dlsB (B:)
aveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikkewiedpklg
kvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfafidrhprldeplasy
ifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaaylergklfytfcgtie
ycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaaihppylvskelmsl
vsgllqpvperrttleklvtdpwvtqpvnladytweevfr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3dlsC (C:)
maleeppkaveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikke
kvledcwiedpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfaf
idrhprldeplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaayl
ergklfytfcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaa
ihppylvskelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevfrvnkpes
gvlsaaslemgnrslsdvaqaqelcggeghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dlsC (C:)
aveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikkekviedpkl
gkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfafidrhprldeplas
yifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaaylergklfytfcgti
eycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaaihppylvskelms
lvsgllqpvperrttleklvtdpwvtqpvnladytweevfr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3dlsD (D:)
maleeppkaveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikke
kvledcwiedpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfaf
idrhprldeplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaayl
ergklfytfcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaa
ihppylvskelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevfrvnkpes
gvlsaaslemgnrslsdvaqaqelcggeghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dlsD (D:)
aveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikkekvldcwie
dpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfafidrhprlde
plasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaaylergklfytf
cgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaaihppylvsk
elmslvsgllqpvperrttleklvtdpwvtqpvnladytweevf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3dlsE (E:)
maleeppkaveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikke
kvledcwiedpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfaf
idrhprldeplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaayl
ergklfytfcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaa
ihppylvskelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevfrvnkpes
gvlsaaslemgnrslsdvaqaqelcggeghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dlsE (E:)
aveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikkekvwiedpk
lgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfafidrhprldepla
syifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaaylergklfytfcgt
ieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaaihppylvskelm
slvsgllqpvperrttleklvtdpwvtqpvnladytweevfr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3dlsF (F:)
maleeppkaveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikke
kvledcwiedpklgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfaf
idrhprldeplasyifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaayl
ergklfytfcgtieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaa
ihppylvskelmslvsgllqpvperrttleklvtdpwvtqpvnladytweevfrvnkpes
gvlsaaslemgnrslsdvaqaqelcggeghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3dlsF (F:)
aveleglaacegeysqkystmsplgsgafgfvwtavdkeknkevvvkfikkekvwiedpk
lgkvtleiailsrvehaniikvldifenqgffqlvmekhgsgldlfafidrhprldepla
syifrqlvsavgylrlkdiihrdikdeniviaedftiklidfgsaaylergklfytfcgt
ieycapevlmgnpyrgpelemwslgvtlytlvfeenpfceleetveaaihppylvskelm
slvsgllqpvperrttleklvtdpwvtqpvnladytweevf