PDB entry 3dkj

View 3dkj on RCSB PDB site
Description: Crystal structure of human NAMPT complexed with benzamide and phosphoribosyl pyrophosphate
Class: transferase
Keywords: TRANSFERASE, NMPRTase, Visfatin, benzamide, phosphoribosyl pyrophosphate, PRPP, nicotinamide phosphoribosyltransferase, Alternative splicing, Cytoplasm, Glycosyltransferase, Phosphoprotein, Polymorphism, Pyridine nucleotide biosynthesis
Deposited on 2008-06-25, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dkja1, d3dkja2
  • Chain 'B':
    Compound: Nicotinamide phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Gene: NAMPT, PBEF, PBEF1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3dkjb1, d3dkjb2
  • Heterogens: PRP, UNU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dkjA (A:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlni

    Sequence, based on observed residues (ATOM records): (download) 
    >3dkjA (A:)
fnillatdsykvthykqyppntskvysyfecreyeetvfyglqyilnkylkgkvvtkeki
qeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftventdpe
cywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyrgvss
qetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdhekd
afehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnpldt
vlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsieniaf
gsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpagnf
vtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlni

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dkjB (B:)
mnpaaeaefnillatdsykvthykqyppntskvysyfecrekktensklrkvkyeetvfy
glqyilnkylkgkvvtkekiqeakdvykehfqddvfnekgwnyilekydghlpieikavp
egfviprgnvlftventdpecywltnwietilvqswypitvatnsreqkkilakyllets
gnldgleyklhdfgyrgvssqetagigasahlvnfkgtdtvaglalikkyygtkdpvpgy
svpaaehstitawgkdhekdafehivtqfssvpvsvvsdsydiynacekiwgedlrhliv
srstqapliirpdsgnpldtvlkvleilgkkfpvtenskgykllppylrviqgdgvdint
lqeivegmkqkmwsieniafgsgggllqkltrdllncsfkcsyvvtnglginvfkdpvad
pnkrskkgrlslhrtpagnfvtleegkgdleeygqdllhtvfkngkvtksysfdeirkna
qlni

    Sequence, based on observed residues (ATOM records): (download) 
    >3dkjB (B:)
fnillatdsykvthykqyppntskvysyfecreyeetvfyglqyilnkylkgkvvtkeki
qeakdvykehfqddvfnekgwnyilekydghlpieikavpegfviprgnvlftventdpe
cywltnwietilvqswypitvatnsreqkkilakylletsgnldgleyklhdfgyrgvss
qetagigasahlvnfkgtdtvaglalikkyygtkdpvpgysvpaaehstitawgkdhekd
afehivtqfssvpvsvvsdsydiynacekiwgedlrhlivsrstqapliirpdsgnpldt
vlkvleilgkkfpvtenskgykllppylrviqgdgvdintlqeivegmkqkmwsieniaf
gsgggllqkltrdllncsfkcsyvvtnglginvfkdpvadpnkrskkgrlslhrtpagnf
vtleegkgdleeygqdllhtvfkngkvtksysfdeirknaqlni