PDB entry 3dk6
View 3dk6 on RCSB PDB site
Description: Crystal structure of mutant ABL kinase domain in complex with small molecule fragment
Class: transferase
Keywords: DRUG DISCOVERY, ABL KINASE, FRAGMENT BASED, Alternative splicing, ATP-binding, Cell adhesion, Chromosomal rearrangement, Cytoplasm, Cytoskeleton, Kinase, Lipoprotein, Magnesium, Manganese, Metal-binding, Myristate, Nucleotide-binding, Nucleus, Phosphoprotein, Proto-oncogene, SH2 domain, SH3 domain, Transferase
Deposited on
2008-06-24, released
2008-07-29
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.02 Å
R-factor: 0.216
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Mus musculus [TaxId:10090]
Gene: Abl1, Abl
Database cross-references and differences (RAF-indexed):
- Uniprot P00520 (3-End)
- engineered (23)
- engineered (215)
Domains in SCOPe 2.05: d3dk6a_ - Chain 'B':
Compound: Proto-oncogene tyrosine-protein kinase ABL1
Species: Mus musculus [TaxId:10090]
Gene: Abl1, Abl
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.05: d3dk6b_ - Heterogens: SX7, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3dk6A (A:)
msldkwemertditmkhklgggqfgevyegvwkkysltvavktlkedtmeveeflkeaav
mkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqiss
ameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtape
slaynkfsiksdvwafgvllweiatygmspypgidpsqvyellekdyrmerpegcpekvy
elmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkrgeghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3dk6A (A:)
dkwemertditmkhklgqfgevyegvwkkysltvavktleveeflkeaavmkeikhpnlv
qllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqissameylekknf
ihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsik
sdvwafgvllweiatygmspypgidpsqvyellekdyrmerpegcpekvyelmracwqwn
psdrpsfaeihqafetmfqessi
- Chain 'B':
Sequence, based on SEQRES records: (download)
>3dk6B (B:)
msldkwemertditmkhklgggqfgevyegvwkkysltvavktlkedtmeveeflkeaav
mkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqiss
ameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtape
slaynkfsiksdvwafgvllweiatygmspypgidpsqvyellekdyrmerpegcpekvy
elmracwqwnpsdrpsfaeihqafetmfqessisdevekelgkrgeghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3dk6B (B:)
kwemertditmkhkevyegvwkkysltvavktleveeflkeaavmkeikhpnlvqllgvc
treppfyiitefmtygnlldylrecnrqevsavvllymatqissameylekknfihrdla
arnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvwaf
gvllweiatygmspypgidpsqvyellekdyrmerpegcpekvyelmracwqwnpsdrps
faeihqafetmfqessisde