PDB entry 3did

View 3did on RCSB PDB site
Description: Crystal structure of the F87M/L110M mutant of human transthyretin at pH 4.6 soaked
Class: ligand binding protein
Keywords: transthyretin, monomer, amyloidogenic intermediate, acidic ph, thyroid hormone binding protein, ligand binding protein
Deposited on 2008-06-20, released 2008-07-22
The last revision prior to the SCOP 1.75 freeze date was dated 2008-07-22, with a file datestamp of 2008-07-18.
Experiment type: XRAY
Resolution: 1.78 Å
R-factor: 0.185
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR PLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered (86)
      • engineered (109)
    Domains in SCOP 1.75: d3dida1
  • Chain 'B':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR PLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered (86)
      • engineered (109)
    Domains in SCOP 1.75: d3didb1
  • Chain 'C':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR PLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered (86)
      • engineered (109)
    Domains in SCOP 1.75: d3didc1
  • Chain 'D':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: TTR PLAB
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered (86)
      • engineered (109)
    Domains in SCOP 1.75: d3didd1
  • Heterogens: ZN, ACT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3didA (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >3didA (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3didB (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >3didB (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3didC (C:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >3didC (C:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtnp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3didD (D:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispmhehaevvftandsgprrytiaamlspysystta
vvtnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >3didD (D:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispmhehaevvftandsgprrytiaamlspysysttavvtn