PDB entry 3ddw

View 3ddw on RCSB PDB site
Description: Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK055
Class: transferase
Keywords: Glycogen Phosphorylase, GP, Diabetes, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Glycogen metabolism, Glycogen storage disease, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Pyridoxal phosphate, Transferase
Deposited on 2008-06-06, released 2009-01-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.154
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen phosphorylase, liver form
    Species: Homo sapiens [TaxId:9606]
    Gene: PYGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3ddwa_
  • Chain 'B':
    Compound: Glycogen phosphorylase, liver form
    Species: Homo sapiens [TaxId:9606]
    Gene: PYGL
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3ddwb_
  • Heterogens: NBG, PLP, CFF, 055, MES, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ddwA (A:)
    ggakpltdqekrrqisirgivgvenvaelkksfnrhlhftlvkdrnvattrdyyfalaht
    vrdhlvgrwirtqqhyydkcpkrvyylslefymgrtlqntminlglqnacdeaiyqlgld
    ieeleeieedaglgngglgrlaacfldsmatlglaaygygiryeygifnqkirdgwqvee
    addwlrygnpweksrpefmlpvhfygkvehtntgtkwidtqvvlalpydtpvpgymnntv
    ntmrlwsarapndfnlrdfnvgdyiqavldrnlaenisrvlypndnffegkelrlkqeyf
    vvaatlqdiirrfkaskfgstrgagtvfdafpdqvaiqlndthpalaipelmrifvdiek
    lpwskaweltqktfaytnhtvlpealerwpvdlvekllprhleiiyeinqkhldrivalf
    pkdvdrlrrmslieeegskrinmahlcivgshavngvakihsdivktkvfkdfselepdk
    fqnktngitprrwlllcnpglaeliaekigedyvkdlsqltklhsflgddvflrelakvk
    qenklkfsqfleteykvkinpssmfdvqvkriheykrqllnclhvitmynrikkdpkklf
    vprtviiggkaapgyhmakmiiklitsvadvvnndpmvgsklkviflenyrvslaekvip
    atdlseqistagteasgtgnmkfmlngaltigtmdganvemaeeageenlfifgmriddv
    aaldkkgyeakeyyealpelklvidqidngffspkqpdlfkdiinmlfyhdrfkvfadye
    ayvkcqdkvsqlymnpkawntmvlkniaasgkfssdrtikeyaqniwnvepsdlkislsn
    esnkvngn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ddwA (A:)
    qisirgivgvenvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtq
    qhyydkcpkrvyylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedagl
    gngglgrlaacfldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpwek
    srpefmlpvhfygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapnd
    gdyiqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfgst
    rgagtvfdafpdqvaiqlndthpalaipelmrifvdieklpwskaweltqktfaytnhtv
    lpealerwpvdlvekllprhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskri
    nmahlcivgshavngvakihsdivktkvfkdfselepdkfqnktngitprrwlllcnpgl
    aeliaekigedyvkdlsqltklhsflgddvflrelakvkqenklkfsqfleteykvkinp
    ssmfdvqvkriheykrqllnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmi
    iklitsvadvvnndpmvgsklkviflenyrvslaekvipatdlseqistagteasgtgnm
    kfmlngaltigtmdganvemaeeageenlfifgmriddvaaldkkgyeakeyyealpelk
    lvidqidngffspkqpdlfkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawnt
    mvlkniaasgkfssdrtikeyaqniwnveps
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3ddwB (B:)
    ggakpltdqekrrqisirgivgvenvaelkksfnrhlhftlvkdrnvattrdyyfalaht
    vrdhlvgrwirtqqhyydkcpkrvyylslefymgrtlqntminlglqnacdeaiyqlgld
    ieeleeieedaglgngglgrlaacfldsmatlglaaygygiryeygifnqkirdgwqvee
    addwlrygnpweksrpefmlpvhfygkvehtntgtkwidtqvvlalpydtpvpgymnntv
    ntmrlwsarapndfnlrdfnvgdyiqavldrnlaenisrvlypndnffegkelrlkqeyf
    vvaatlqdiirrfkaskfgstrgagtvfdafpdqvaiqlndthpalaipelmrifvdiek
    lpwskaweltqktfaytnhtvlpealerwpvdlvekllprhleiiyeinqkhldrivalf
    pkdvdrlrrmslieeegskrinmahlcivgshavngvakihsdivktkvfkdfselepdk
    fqnktngitprrwlllcnpglaeliaekigedyvkdlsqltklhsflgddvflrelakvk
    qenklkfsqfleteykvkinpssmfdvqvkriheykrqllnclhvitmynrikkdpkklf
    vprtviiggkaapgyhmakmiiklitsvadvvnndpmvgsklkviflenyrvslaekvip
    atdlseqistagteasgtgnmkfmlngaltigtmdganvemaeeageenlfifgmriddv
    aaldkkgyeakeyyealpelklvidqidngffspkqpdlfkdiinmlfyhdrfkvfadye
    ayvkcqdkvsqlymnpkawntmvlkniaasgkfssdrtikeyaqniwnvepsdlkislsn
    esnkvngn
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ddwB (B:)
    nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
    yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
    fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
    ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfnlrdgdyiqa
    vldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfggtvfdafp
    dqvaiqlndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpealerwpvd
    lvekllprhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinmahlcivgsh
    avngvakihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglaeliaekiged
    yvkdlsqltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssmfdvqvkri
    heykrqllnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiiklitsvadvv
    nndpmvgsklkviflenyrvslaekvipatdlseqistagteasgtgnmkfmlngaltig
    tmdganvemaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvidqidngff
    spkqpdlfkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvlkniaasgk
    fssdrtikeyaqniwnveps