PDB entry 3db6

View 3db6 on RCSB PDB site
Description: Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902
Class: transferase
Keywords: Polo-like kinase 1, Plk1, catalytic domain, small-molecule inhibitor, Kinase, TRANSFERASE
Deposited on 2008-05-30, released 2008-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.225
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polo-like kinase 1
    Species: Danio rerio [TaxId:7955]
    Gene: PLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4KMI8
      • engineered (184)
    Domains in SCOPe 2.08: d3db6a_
  • Heterogens: FRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3db6A (A:)
gplgsdpksaplkeipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvp
ksmllkphqkekmsteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrr
kavtepearyfmrqtiqgvqylhnnrvihrdlklgnlflnddmdvkigdfglatkiefdg
erkkdlcgtpnyiapevlckkghsfevdiwslgcilytllvgkppfetsclketyirikk
neysvprhinpvasalirrmlhadptlrpsvaelltdefftsgyapmrlptscltvpprf
s

    Sequence, based on observed residues (ATOM records): (download) 
    >3db6A (A:)
keipdvlvdprtmkrymrgrflgkggfakcyeitdmdtkevfagkvvpksmllkphqkek
msteiaihksldnphvvgfhgffedddfvyvvleicrrrsllelhkrrkavtepearyfm
rqtiqgvqylhnnrvihrdlklgnlflnddmdvkigdfglatkiefdgerkkdlcgtpny
iapevlckkghsfevdiwslgcilytllvgkppfetsclketyirikkneysvprhinpv
asalirrmlhadptlrpsvaelltdefftsgyapmrlptscltvppr