PDB entry 3day

View 3day on RCSB PDB site
Description: Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in complex with AMP-CPP
Class: ligase
Keywords: middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, structural genomics consortium, sgc, ATP-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase
Deposited on 2008-05-30, released 2008-07-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2A, ACSM2, MACS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered (56)
    Domains in SCOPe 2.08: d3daya_
  • Heterogens: MG, CL, APC, TRS, UNX, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dayA (A:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3dayA (A:)
lqwghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqq
aanvlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqms
kakaivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgs
qeasaiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcs
lmepwalgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlq
ncvtvgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydv
qiiddkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikde
dgyfqfmgraddiinssgyrigpsevenalmehpavvetavisspdrgevvkafvvlasq
flshdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk