PDB entry 3dax

View 3dax on RCSB PDB site
Description: Crystal structure of human CYP7A1
Class: oxidoreductase
Keywords: cytochrome p450, cholesterol, cholesterol 7-alpha hydroxylase, Structural Genomics, Structural Genomics Consortium, SGC, Cholesterol metabolism, Endoplasmic reticulum, Heme, Iron, Lipid metabolism, Membrane, Metal-binding, Microsome, Monooxygenase, NADP, Oxidoreductase, Polymorphism, Steroid metabolism
Deposited on 2008-05-30, released 2008-08-05
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.19
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 7A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP7A1, CYP7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22680 (7-485)
      • expression tag (6)
      • expression tag (486-487)
    Domains in SCOPe 2.04: d3daxa_
  • Chain 'B':
    Compound: Cytochrome P450 7A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP7A1, CYP7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22680 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.04: d3daxb_
  • Heterogens: HEM, UNX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3daxA (A:)
makktssrrrqtgepplenglipylgcalqfganpleflranqrkhghvftcklmgkyvh
fitnplsyhkvlchgkyfdwkkfhfatsakafghrsidpmdgnttenindtfiktlqgha
lnsltesmmenlqrimrppvssnsktaawvtegmysfcyrvmfeagyltifgrdltrrdt
qkahilnnldnfkqfdkvfpalvaglpihmfrtahnareklaeslrhenlqkresiseli
slrmflndtlstfddlekakthlvvlwasqantipatfwslfqmirnpeamkaateevkr
tlenagqkvslegnpiclsqaelndlpvldsiikeslrlssaslnirtakedftlhledg
synirkddiialypqlmhldpeiypdpltfkydryldengktkttfycnglklkyyympf
gsgaticpgrlfaiheikqflilmlsyfeleliegqakcppldqsraglgilpplndief
kykfkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3daxA (A:)
srrrqtgepplenglipylgcalqfganpleflranqrkhghvftcklmgkyvhfitnpl
syhkvlchgkyfdwkkfhfatsakafghrsidpmdgnttenindtfiktlqghalnslte
smmenlqrimrawvtegmysfcyrvmfeagyltifgrdltrrdtqkahilnnldnfkqfd
kvfpalvaglpihmfrtahnareklaeslrhenlqkresiselislrmflndtlstfddl
ekakthlvvlwasqantipatfwslfqmirnpeamkaateevkrtlenagqkvslegnpi
clsqaelndlpvldsiikeslrlssaslnirtakedftlhledgsynirkddiialypql
mhldpeiypdpltfkydryldengktkttfycnglklkyyympfgsgaticpgrlfaihe
ikqflilmlsyfeleliegqakcppldqsraglgilpplndiefkykfkhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3daxB (B:)
makktssrrrqtgepplenglipylgcalqfganpleflranqrkhghvftcklmgkyvh
fitnplsyhkvlchgkyfdwkkfhfatsakafghrsidpmdgnttenindtfiktlqgha
lnsltesmmenlqrimrppvssnsktaawvtegmysfcyrvmfeagyltifgrdltrrdt
qkahilnnldnfkqfdkvfpalvaglpihmfrtahnareklaeslrhenlqkresiseli
slrmflndtlstfddlekakthlvvlwasqantipatfwslfqmirnpeamkaateevkr
tlenagqkvslegnpiclsqaelndlpvldsiikeslrlssaslnirtakedftlhledg
synirkddiialypqlmhldpeiypdpltfkydryldengktkttfycnglklkyyympf
gsgaticpgrlfaiheikqflilmlsyfeleliegqakcppldqsraglgilpplndief
kykfkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3daxB (B:)
srrrqtgepplenglipylgcalqfganpleflranqrkhghvftcklmgkyvhfitnpl
syhkvlchgkyfdwkkfhfatsakafghrsidpmdgnttenindtfiktlqghalnslte
smmenlqrimraawvtegmysfcyrvmfeagyltifgrdltrrdtqkahilnnldnfkqf
dkvfpalvaglpihmfrtahnareklaeslrhenlqkresiselislrmflndtlstfdd
lekakthlvvlwasqantipatfwslfqmirnpeamkaateevkrtlenagqkvslegnp
iclsqaelndlpvldsiikeslrlssaslnirtakedftlhledgsynirkddiialypq
lmhldpeiypdpltfkydryldengktkttfycnglklkyyympfgsgaticpgrlfaih
eikqflilmlsyfeleliegqakcppldqsraglgilpplndiefkykfk