PDB entry 3d7v
View 3d7v on RCSB PDB site
Description: Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
Class: apoptosis
Keywords: helical bundle, amphipathic helix, Alternative splicing, Apoptosis, Cytoplasm, Developmental protein, Differentiation, Membrane, Mitochondrion, Nucleus, Phosphoprotein, Polymorphism, Transmembrane, Ubl conjugation
Deposited on
2008-05-22, released
2008-06-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-08-23, with a file datestamp of
2017-08-18.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: N/A
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
Species: Homo sapiens [TaxId:9606]
Gene: MCL1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d3d7va_ - Chain 'B':
Compound: Bcl-2-like protein 11
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Uniprot O43521
- engineered (11)
- engineered (18)
- Heterogens: ZN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3d7vA (A:)
gplgseddlyrqsleiisrylreqatgskdskplgeagaagrraletlrrvgdgvqrnhe
tafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqes
cieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg
Sequence, based on observed residues (ATOM records): (download)
>3d7vA (A:)
ddlyrqsleiisrylreqatgskdgaagrraletlrrvgdgvqrnhetafqgmlrkldik
neddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitdvl
vrtkrdwlvkqrgwdgfveffhve
- Chain 'B':
No sequence available.